穴位贴敷中药方对慢性阻塞性肺疾病稳定期患者肺功能的影响

Effect of Acupoint Application of Traditional Chinese Medicine on Pulmonary Function in Patients with Stable Chronic Obstructive Pulmonary Disease

目的:观察自拟穴位贴敷中药方对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者肺功能指标的影响。方法:64例COPD稳定期患者随机分成观察组和对照组各32例。对照组给予舒利迭,观察组在此基础上给予自拟穴位贴敷中药方。比较两组的临床疗效、治疗前后的肺功能指标水平及中医证候积分,分析中医证候总积分与肺功能指标的相关性。结果:观察组有效率为96.88%,对照组有效率为71.88%,两组比较,差异有统计学意义(P<0.05);观察组治疗后用力肺活量(forced vital capacity,FVC)及第1秒用力呼气容积(forced expiratory volume in one second,FEV1)水平显著高于对照组,差异均有统计学意义(均P<0.05);但两组治疗前后的最大通气量(maximal voluntary ventilation,MVV)、残气量(residual volume,RV)及最大呼气峰流速(peak expiratory flow,PEF)水平比较,差异无统计学意义(P>0.05);治疗后观察组咳嗽、咳痰、气促、胸闷及中医证候总积分均显著低于对照组,差异均有统计学意义(均P<0.05);根据Spearman法分析相关性可知,中医证候总积分与COPD患者的FVC及FEV1均呈显著负相关,但与MVV、RV及PEF无明显相关性。结论:自拟穴位贴敷中药方对稳定期COPD患者具有较好的疗效,还可有效稳定及改善患者肺功能。

Objective： To study the effect of self-made acupoint application of traditional Chinese medicine on lung function index in patients with stable chronic obstructive pulmonary disease（ COPD） in stable period. Methods： 64 patients with stable COPD were randomly divided into observation group and control group with 32 cases in each,according to the random digital method. The two group was given routine drug treatment,the observation group on the basis of Seretide treated with self-made acupoint prescription.Compared the clinical efficacy,lung function index and the total score of TCM symptoms before and after treatment of two groups,and analyzed the correlation between the total score of TCM symptoms and lung function index. Results： The total efficiency of the observation group was 96. 88%（ 31 /32）,significantly higher than 71. 88%（ 23 /32） of the control group,the difference was statistically significant（ P〈0. 05）. After treatment,the forced vital capacity（ FVC） and forced expiratory volume in one second（ FEV1） of the observation group was significantly higher than these of the control group,the differences were statistically significant（ P〈0. 05）. There was no the difference in maximal ventilatory volume（ MVV）,residual volume（ RV） and maximum peak expiratory flow（ PEF） comparing between before and after treatment in two groups（ P〉0. 05）. After treatment,the score of cough,expectoration,shortness of breath,chest tightness and total score of TCM syndrome in observation group was significantly lower than that of the control group,the differences were statistically significant（ P〈0. 05）. Spearman correlation analysis showedthat the total score of TCM syndrome was negatively related to FVC and FEV1 of COPD patients but it had no obvious correlation with MVV,RV and PEF. Conclusion： Self-made acupoint prescription on patients with stable COPD has better curative effect,also can effectively stabilize and improve the patient＇s lung function,the effect is obvious,it is worth clinical recommendations.