补肾益髄方对老年性痴呆肾虚髓亏证患者ADAS-cog积分的影响

The Effect of Bushenyisui Decoction on Senile Dementia Kidney Deficiency Syndrome ADAS-cog Points

目的:观察补肾益髄方对老年性痴呆肾虚髓亏证患者阿尔茨海默病评估量表(Alzhermer's disease assessment scale,ADAS)-cog积分的影响。方法:对照组给予盐酸多奈哌齐及补肾益髓方免煎颗粒剂模拟剂口服。治疗组给予补肾益髓方(淫羊藿、补骨脂、制首乌、女贞子、黄芪、川芎、石菖蒲)免煎颗粒剂及盐酸多奈哌齐模拟剂口服。服药方法:补肾益髓方免煎颗粒剂及其模拟剂温开水冲服,每日1次。盐酸多奈哌齐及其模拟剂睡前口服5 mg,每日1次。24周后观察两组ADAS-cog的总积分和各分项积分的分值变化。结果:治疗组治疗前后各分项积分及总积分比较,差异无统计学意义(P>0.05)。治疗后治疗组的总积分差值与对照组比较,差异有统计学意义(P<0.05)。治疗组口头语言能力方面的积分改善优于对照组,差异有统计学意义(P<0.05)。治疗组ADAS-cog有效率29.41%,对照组8.82%,两组比较,差异有统计学意义(P<0.05)。结论:补肾益髓方能降低ADAS-cog总积分及部分分项积分,治疗老年性痴呆疗效显著。

Objective： To observe the effect of Bushenyisui Decoction Senile dementia kidney deficiency syndrome ADAS-cog（ Alzhermer＇s disease assessment scale,ADAS） points. Methods： the control group was treated with donepezil hydrochloride and Bushen Yisui Decoction Decoction granules simulation agent. The treatment group was given oral Bushen Yisui Decoction（ epimedium,psoralea fruit,Radix Polygoni Multiflori,privet fruit,Radix Astragali,Rhizoma Chuanxiong,Shi Changpu） free Decoction and donepezil hydrochloride simulated agent oral. Medication methods： Bushenyisui Decoction and its simulation agent warm boiling water,1 times a day. Before oral donepezil hydrochloride simulated agent 5mg score total score of two group ADAS-cog the score of each item and the 1 times a day after 24 weeks of observation. Results： Compare the points of each item and total points of treatment group before and after treatment,there was no statistically significant difference（ P〉0. 05）. The treatment group after treatment,the total score was different with the control group,and the difference was statistically significant（ P〈0. 05）. Treatment group oral language ability points was better than the control group,the difference was statistically significant（ P〈0. 05）. Treat-ment group ADAS cog has efficiency 29. 41%,control group 8. 82%,the difference of two groups had a statistical significance（ P〈0. 05）. Conclusion： Bushenyisui Decoction was effective in decreasing the integral of ADAS cog total score and part of the sub,which had significant effect in the treatment of senile dementia.