逐瘀活络针刺法治疗原发性三叉神经痛临床研究

Clinical Study on Zhuyu Huoluo Acupuncture Treatment of Primary Trigeminal Neuralgia

目的:探讨逐瘀活络针刺法治疗原发性三叉神经痛(瘀阻脑络证)的临床疗效和安全性。方法:选择符合要求的100例原发性三叉神经痛(瘀阻脑络证)患者随机分为对照组和观察组各50例。对照组采用卡马西平片治疗,观察组采用逐瘀活络针刺法。两组疗程均为4周。并进行3个月的随访。比较两组治疗前后主要症状评分和疼痛视觉模拟评分法(visual analogue scale,VAS)评分、匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)、汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)和汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评分,并记录不良反应。结果:观察组者有效率为94%,高于对照组的78%(χ2=5.315,P<0.05);治疗后观察组主要症状评分和VAS评分均低于对照组(P<0.01);观察组HAMA、HAMD和PSQL量表评分低于对照组(P<0.01);对照组不良反应发生率为24%,高于观察组的2%(χ2=14.513,P<0.01)。结论:逐瘀活络针刺法治疗原发性三叉神经痛(瘀阻脑络证),在改善患者临床症状,降低VAS评分,提高睡眠质量,改善患者负性情绪和提高临床有效率方面均优于卡马西平,且临床使用安全。

Objective： To investigate the clinical efficacy and safety of Zhuyu Huoluo acupuncture in the treatment of primary trigeminal neuralgia（ blood stasis blocking brain collaterals type）. Methods： 100 cases of primary trigeminal neuralgia（ blood stasis blocking brain collaterals） were randomly divided into control group and observation group,each 50 cases. The control group was given Carbamazepine tablets,and the observation group was treated with Zhuyu Huoluo acupuncture method. Two groups were treated for 4 weeks and 3 months of follow-up. Compared the two groups before and after treatment,the main symptoms scores and visual analogue scale（ VAS）,pittsburgh sleep quality index（ PSQI）,Hamilton Anxiety Scale（ HAMA）,and Hamilton Anxiety Scale（ HAMA） score and recorded adverse reactions. Results： In the observation group,the effective rate was 94%,which was higher than that of control group of 78%（ χ2= 5. 315,P〈0. 05）; after treatment,main symptoms and VAS scores in the observation group were lower than the control group（ P〈0. 01）; HAMA,HAMD and PSQL table score in the observation group was lower than that of control group（ P〈0. 01）; the total adverse reaction incidence rate in the control group was 24%,which was higher than the observation group of 2%（ χ2= 14. 513,P〈0. 01）. Conclusion： Zhuyu Huoluo acupuncture therapy in the treatment of primary trigeminal neuralgia（ blood stasis blocking brain collaterals type） is superior to carbamazepine in improving the clinical symptoms of the patients,reduce VAS score,improve sleep quality,improve the negative emotion of patients with and improve clinical efficiency,and the safety of clinical use.