免疫球蛋白A肾病发病机制及相关血清标志物

Pathogenesis and relevant serum biomarkers of immunoglobulin A nephropathy

免疫球蛋白A(Ig A)肾病是目前世界范围内最常见的原发性肾小球疾病。糖基化缺陷的Ig A1分子引起自身免疫反应,是Ig A肾病发病的始动机制。近年来,在Ig A肾病发病机制和标志物方面的研究取得了显著进展,这为Ig A肾病的非侵入性诊断、疾病活动监测和疾病特异性治疗提供了基础。该文就Ig A肾病发病的分子机制和重要血清标志物的研究进展作一综述。

Immunoglobulin A（IgA） nephropathy is the most prevalent primary chronic glomerular disease worldwide.The autoimmune response caused by galactose-deficient polymeric IgAl is the original mechanism triggering the IgA nephropathy.Significant research advances in pathogenesis and biomarkers of IgA nephropathy have been made in recent years and provide the basis for noninvasive diagnosis,monitoring of disease activity,and disease-specific therapies.The research advances in molecular mechanisms and key serum biomarkers in the pathogenesis of IgA nephropathy are reviewed in this paper.