脂代谢及血清骨钙素水平与骨质疏松症的相关性分析

The correlation analysis between the level of lipid metabolism and osteocalcin and osteoporosis

目的探讨脂代谢与血清骨钙素(osteocalcin,OSC;bone glaprotein,BGP)水平与骨质疏松症的相关性。方法选取2014年3月至2015年3月我院风湿科门诊患者及体检科收治的体检者,观察组为418例确诊骨质疏松症患者,对照组为无骨质疏松症状的396例健康者。分析两组患者脂代谢及血清骨钙素水平与骨质疏松症相关性。结果观察组的总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL-L)高于对照组,高密度脂蛋白(HDL-L)水平、血清骨钙素水平降低,具统计学意义,且骨钙素和TG呈负相关。结论脂代谢障碍、血清骨钙素的减少具有影响骨代谢、加快骨吸收的作用,并由此影响骨质疏松症的发病。

Objective To study the correlation between the level of lipid metabolism and osteocalcin（ OC） and osteoporosis.Methods A total of 814 patients in our hospital from March 2014 to March 2015 were selected. Among those,418 patients with osteoporosis were enrolled in the observation group and 396 non-osteoporosis people were enrolled in the control group. The level of lipid metabolism and OC and their correlation with osteoporosis were analyzed. Results The levels of TC,TG,and LDL-L in the observation group were higher,but HDL-L and OC were lower than those in the control group. The difference was significant（ P 〈0. 05）. OC was negatively associated with TG. Conclusion Disorder of lipid metabolism and reduction of OC play a role in bone metabolism,which is important in the pathogenesis of osteoporosis.