摘要
目的探讨第二代药物洗脱支架(DES)治疗无保护左主干冠状动脉(ULMCA)病变的疗效。方法接受DES治疗的ULMCA病变患者216例分为两组:F组121例,采用第一代DES治疗;S组95例,采用第二代DES治疗。术后常规服用阿司匹林100mg/d和氯吡格雷150mg/d,至少1年,随访1年。结果 ULMCA病变狭窄程度为(68.8±14.2)%。S组主要心血管不良事件发生率低于F组(5.3%vs.14.0%)(P<0.05)。S组靶血管血运重建发生率低于F组(3.2%vs.10.7%)(P<0.05)。两组术后ULMCA最小管腔直径及管腔狭窄程度均较术前改善(P<0.05)。结论与第一代DES比较,第二代DES治疗ULMCA病变具有更好的疗效和安全性。
Objective To explore the efficacy of second-generation drug-eluting stents(DES)in treating the patients with unprotected left main coronary artery(ULMCA).Methods A total of 216 patients with ULMCA was assigned into two groups of A(treated with first-generation DES,121cases)and B(treated with second-generation DES,95cases).Oral asprin 100 mg/d and clopidogrel150mg/d were performed at least for one year after treatment.The patients were followed up for one year.Results Stenosis of ULMCA of 216 patients was(68.8±14.2)%.During follow up of(342±23)days,the incidence of major adverse cardiovascular events(MACE)in group B was lower than that in group A(5.3% vs.14.0%)(P〈0.05).So did the incidence of target vessel revascularization(3.2% vs.10.7%)(P〈0.05).Compared to before,minimum lumendiameter of ULMCA and stenosis degree after treatment were improved in both groups(P〈0.05).Conclusion Compared to first-generation DES,the second-generation DES has better efficacy and safety in treating the patients with ULMCA.
出处
《江苏医药》
CAS
2016年第11期1247-1250,共4页
Jiangsu Medical Journal