第二代药物洗脱支架治疗无保护左主干冠状动脉病变的疗效

Efficacy of second-generation drug-eluting stents in treating patients with unprotected left main coronary artery

目的探讨第二代药物洗脱支架(DES)治疗无保护左主干冠状动脉(ULMCA)病变的疗效。方法接受DES治疗的ULMCA病变患者216例分为两组:F组121例,采用第一代DES治疗;S组95例,采用第二代DES治疗。术后常规服用阿司匹林100mg/d和氯吡格雷150mg/d,至少1年,随访1年。结果 ULMCA病变狭窄程度为(68.8±14.2)%。S组主要心血管不良事件发生率低于F组(5.3%vs.14.0%)(P<0.05)。S组靶血管血运重建发生率低于F组(3.2%vs.10.7%)(P<0.05)。两组术后ULMCA最小管腔直径及管腔狭窄程度均较术前改善(P<0.05)。结论与第一代DES比较,第二代DES治疗ULMCA病变具有更好的疗效和安全性。

Objective To explore the efficacy of second-generation drug-eluting stents（DES）in treating the patients with unprotected left main coronary artery（ULMCA）.Methods A total of 216 patients with ULMCA was assigned into two groups of A（treated with first-generation DES,121cases）and B（treated with second-generation DES,95cases）.Oral asprin 100 mg/d and clopidogrel150mg/d were performed at least for one year after treatment.The patients were followed up for one year.Results Stenosis of ULMCA of 216 patients was（68.8±14.2）%.During follow up of（342±23）days,the incidence of major adverse cardiovascular events（MACE）in group B was lower than that in group A（5.3% vs.14.0%）（P〈0.05）.So did the incidence of target vessel revascularization（3.2% vs.10.7%）（P〈0.05）.Compared to before,minimum lumendiameter of ULMCA and stenosis degree after treatment were improved in both groups（P〈0.05）.Conclusion Compared to first-generation DES,the second-generation DES has better efficacy and safety in treating the patients with ULMCA.