肺癌患者外周血DNT细胞和T淋巴细胞亚群检测的临床意义

Clinical Significance of Detection of DNT and T Lymphocyte Subsets in Peripheral Blood of Cancer Patients

目的分析肺癌患者外周血DNT细胞和T淋巴细胞亚群检测的临床意义。方法随机抽取73例肺癌患者作为观察组,同时选择同期健康体检者75例作为对照组,采用流式细胞检测仪器对2组受检者外周血DNT细胞和T淋巴细胞亚群水平进行检测,并进行比较。结果观察组外周血DNT细胞水平高于对照组,P<0.05;观察组T淋巴细胞亚群(CD3+、CD4+、CD4+/CD8+)细胞数量低于对照组,但CD8+细胞数量高于对照组,P<0.05。结论肺癌患者外周血DNT细胞明显增多,且T淋巴细胞亚群细胞数量显著减少,提示临床肺癌患者合并严重的免疫功能紊乱现象,要加以重视。

Objective To analyze the clinical significance of DNA in peripheral blood of patients with lung cancer cells and T lymphocyte subsets. Methods 73 cases of patients with lung cancer were randomly selected as the observation group,while 75 cases of healthy people in the same period were selected as a control group,to apply and compare flow cytometry instrument for the detection of the level of DNT cells and peripheral blood T lymphocyte subsets of two groups. Results The level of DNT peripheral blood cell of observation group was significantly higher that of control group,P〈0.05. T lymphocyte subsets（CD3^＋,CD4^＋,CD4^＋ / CD8^＋） cell number of observation group was significantly lower than those of control group,but the number of CD8^＋ cells of observation group was higher than that of control group,P〈0.05. Conclusion The patients with lung cancer DNT cells increased significantly,and the T lymphocyte subsets significantly reduced the number of cells,suggesting that patients with lung cancer combined clinical severe immune dysfunction phenomenon attach the attention.