microRNA与获得性主动脉疾病分子病因的研究进展

Progress in researches of microRNA and molecular etiology of acquired aortic disease

主动脉夹层、主动脉瘤等成人获得性主动脉疾病已成为常见病和多发病，其治疗难度大、风险高，然而发生此类疾病的具体分子病因并不清楚。MicroRNA是一种类似于小干扰RNA的小分子RNA，在某种程度上，几乎所有的生物功能都有microRNA的参与。本文主要回顾miRNA在成人获得性主动脉疾病分子病因方面的相关研究。

Adult acquired aortic disease such as aortic dissection, aortic aneurysm, is common, and the treatment is complicated. Furthermore, the specific molecular etiology of this kind of disease is unknown. MicroRNA, which is a short pep- tide molecule, to some extent, participated in almost every aspect of biological functions. This paper aims to review the role of microRNA in molecular etiology of adult acquired aortic disease.