摘要
目的探讨乙酰辅酶A乙酰转移酶1(ACAT1)在前列腺癌中的表达情况及临床意义。方法采用免疫组化染色,检测63例前列腺癌组织及癌旁正常组织中ACAT1的表达情况。结果 ACAT1在前列腺癌组织及正常前列腺组织中的表达阳性率分别81.0%和20.6%,差异有统计学意义(P<0.05),且与前列腺癌患者年龄、前列腺特异性抗原(PSA)水平无关(P>0.05),但与Gleason score(GS)及肿瘤病理分期有关(P<0.05)。结论ACAT1的表达在前列腺癌组织中显著高于癌旁正常组织,与前列腺癌GS评分和肿瘤病理分期有关。ACAT1可能是早期前列腺癌的标志。
Objective To investigate the expression of ACAT1 in prostate cancer tissue and its clinical significance. Methods Immunohistochemistry was used to detect ACAT1 expression in 63 cases of prostate cancer and normal tissues. Results ACAT1 expressed in prostate cancer tissue and normal prostate tissues were 81.0%, 20.6%, respectively, the difference was statistically significant （P〈0.05）.The expression of ACAT1 was not correlated with age and PSA （P〉0.05）, but it was correlated with Gleason score and pathological stage （P〈0.05）. Conclusion Expression of ACAT1 elevated significantly in prostate cancer tissues than that in normal tissues, and it was significantly correlated with Gleason score and pathological stage.ACAT1 expression could serve as an earlier potential marker of prostate cancer.
出处
《中南医学科学杂志》
CAS
2016年第3期293-295,共3页
Medical Science Journal of Central South China
基金
衡阳市科学技术发展计划项目基金资助项目(ACAT1作为前列腺癌进展中的诊断及预后因子的前瞻性研究
编号:2014KJ51)
