丁苯酞治疗急性脑梗死的临床疗效及其血管内皮功能的影响

Clinical Curative Effect of Butylphthalide on Acute Cerebral Infarction And Its Influence on Vascular Endothelial Function

目的 研究丁苯酞治疗急性脑梗死的临床疗效,以及其对血管内皮功能的影响.方法 将2014年1月～ 2015年1月期间在笔者医院神经内科接受治疗的76例急性脑梗死患者随机均分成两组（即对照组和观察组）,对照组患者接受常规药物治疗,观察组患者接受（丁苯酞＋常规药物）治疗,治疗14天后,统计两组患者的神经功能缺损评分,并对两组的临床疗效进行比较;进一步比较两组患者血管性血友病因子（vWF）、一氧化氮（NO）、血管内皮素（ET-1）、血管内皮生长因子（VEGF）等4种血管内皮功能标志物的表达水平.结果 观察组治疗的总有效率为86.84％,要明显高于对照组的63.16％,且两者的差异存在统计学意义（P＜0.05）;且观察组NO的表达水平为56.17 ±6.42μmol/L,要明显高于对照组,而vWF、ET-1、VEGF的表达水平分别为121.32％±11.56％、78.73±8.36ng/L、208.82±18.96ng/L,均明显低于对照组,差异均有统计学意义（P＜0.05）.结论 丁苯酞在治疗急性脑梗死方面有着更好的临床疗效,且能够修复血管内皮功能损伤,从而改善脑部微循环,缓解脑梗死症状,应该在今后的临床实践中予以推广.

Objective To study the clinical curative effect of Butylphthalide on acute cerebral infarction and its influence on vascular endothelial function.Methods Totally 76 cases of acute cerebral infarction who were treated in our department of neurology from January 2014 to January 2015 were randomly divided into control group and observation group with 38 cases in each group.Subjects in the control group received treatment of conventional drugs,and those in the observation group received treatment of Butylphthalide and Sodium Chloride Injection.14 days after treatment,we compared the clinical curative effect between the two groups by NIHSS,compared the expression levels of the markers of vascular endothelial function （vWF,NO,ET-1,VEGF） between the two groups.Results The total effective rate of the control group was 63.16％,while the observation group was 86.84％.It was significantly higher than the control group （P ＜ 0.05）.The expression level of NO in observation group was56.17 ± 6.42μmol/L,and it was higher than that in control group.The expression levels of vWF、ET-1 、VEGF in observation group were 121.32％ ± 11.56％,78.73 ± 8.36ng/L,208.82 ± 18.96ng/L respectively,and they were lower those that in control group,and the differences were statistical significance （P ＜ 0.05）.Conclusion Butylphthalide has a better clinical curative effect in the treatment of acute cerebral infarction,and it can repair vascular endothelial dysfunction,which improve brain microcirculation and relieve symptoms of cerebral infarction,and it should be promoted in clinical practice in the future.