Ⅰ型胶原蛋白和TGF-β1在食管鳞癌中的表达及临床意义

Expression and Significance of Type Ⅰ Collagen and TGF-beta 1 in Esophageal Squamous Cell Carcinoma

目的 研究Ⅰ型胶原蛋白和TGF-β1在食管鳞癌中的表达及意义.方法 选取2013年1月～2014年12月在笔者医院接受治疗的食管鳞癌患者82例作为研究对象,将其切除的食管鳞癌组织制成标本作为观察组进行研究,另随机选取20例患者取其癌组织旁正常的食管黏膜组织作为对照组,检测两组中Ⅰ型胶原蛋白和TGF-β1的表达情况.并采用单因素分析这两种指标表达的相关性.结果 在癌组织中,Ⅰ型胶原蛋白、TGF-β1均存在异常高表达,差异有统计学意义（P＜0.05）;实施单因素分析,发现Ⅰ型胶原蛋白、TGF-β1的高表达与是否存在淋巴结的转移以及pTNM分期有明显的关系,且发现二者的表达存在明显的正相关性（r =0.744,P=0.000）.结论 在食管鳞癌患者癌组织中,Ⅰ型胶原蛋白以及TGF-β1存在明显的高表达,且这两种指标的表达与肿瘤的浸润深度、pTNM分期以及淋巴结是否转移存在明显的相关性,可见其在食管鳞癌的发生以及发展过程中起到较为重要的作用.

Objective To explore the expression and significance of type Ⅰ collagen and TGF-beta 1 in esophageal squamous cell carcinoma.Methods Eighty-two cases of esophageal squamous cell carcinoma treated in our hospital from January 2013 to December were selected as the research object.The esophageal squamous cell carcinoma tissue was studied as the observation group,and 20 cases of normal esophageal mucosa tissues were selected as the control group,and the expression of type Ⅰ collagen and TGF-1 was detected in the two groups.And single factor analysis was used to analyze the correlation of these two indicators.Results It was found that there was abnormal high expression in tumor tissues,type Ⅰ collagen,TGF-beta 1,and the difference was statistically significant （P ＜ 0.05）.The high expression of type Ⅰ collagen and TGF-beta 1 showed significant positive correlation with the expression of pTNM and P =0.000,and the correlation coefficient was r =0.744,P =0.000.Conclusion In esophageal squamous cell carcinoma,there was obvious high expression of type Ⅰ collagen protein and TGF-beta 1,and the expression of these two indicators had obvious correlation with tumor invasion depth,pTNM stage and lymph node metastasis.