利用数据挖掘技术分析150例ALT<2倍正常值上限的慢性乙型肝炎中医证候规律

Analysis of TCM Syndromes of 150 ALT<2ULN cases of chronic hepatitis B by using data mining technology

目的:系统分析慢性乙型肝炎(CHB)(ALT<2ULN)中医证候组群分布规律和中医证型与各影响因素之间的关系。方法:借助中医临床信息采集系统记录150例CHB(ALT<2ULN)患者的临床症状、体征,应用数据挖掘技术结合统计学处理对其临床症状、体征提取分析,探讨内在规律。结果:肝郁气滞型患者平均年龄最小,脾肾阳虚型平均年龄最大;肝郁脾虚型年龄、病程与其他各组比较有统计学意义(P<0.05);发病率男女性别比差异有显著性意义(P<0.05);HBeAg阳性率湿热蕴结型最高,脾肾阳虚型最低,湿热蕴结型与肝郁脾虚型相比较差异有统计学意义(P<0.05);HBV DNA阳性率湿热蕴结型最高,脾肾阳虚型最低,湿热蕴结型与瘀血阻络型相比较差异有统计学意义(P<0.05)。结论:150例CHB(ALT<2ULN)患者中湿热蕴结型为最常见证型,且其HBeAg与HBV DNA阳性率最高;肝郁气滞型发病年龄最小、病程最短;男性发病率明显高于女性,各证型性别构成与总体发病率无明显差异。CHB病因归于"杂气"学说,病位在肝,病机演变有规律性。

Objective： To analyze the relationship between TCM Syndrome Types and TCM syndrome types of chronic hepatitis B （ ALT 〈 2ULN ）. Methods： By means of ALT 〈 2ULN 150 patients with chronic hepatitis B patients clinical symptoms and signs of TCM clinical information acquisition system records, application data mining technology combined with statistical analysis of the clinical symptoms and signs of extraction and analysis, explore the inner rules. Results： The mean age of patients with stagnation of liver Qi type minimum, spleen kidney yang deficiency type the average age of the largest; syndrome of stagnation of liver qi and deficiency of the spleen age, course of disease and other groups compared with statistical significance （ P 〈 0.05 ） ; incidence of male to female sex ratio had significant difference （ P 〈 0.05 ） ; dampness and heat in HBeAg positive rate is highest, spleen kidney yang deficiency type positive rate lowest heat accumulation type and liver stagnation and spleen deficiency type phase difference has statistical significance （ P 〈 0.05 ）. The positive rate of damp heat accumulation type HBV-DNA positive rate is the highest, spleen kidney yang deficiency type lowest heat accumulation type and blood stasis type phase difference has statistical significance （P 〈0.05 ）. Conclusion ：one hundred and fifty patients with chronic hepatitis B ALT 〈 2ULN in patients with damp heat accumulation type is the most common type of syndrome and the positive rate of HBeAg and HBV-DNA highest; minimum stagnation of liver qi stagnation type of age of onset, duration of shortest; male incidence was significantly higher than females, each card type sex composition and the overall incidence was no significant difference. The etiology of chronic hepatitis B is attributed to the theory of ＂miscellaneous Qi＂. The disease is in the liver, and the pathogenesis of the disease is regular.