季戊四醇支载手性咪唑啉酮催化不对称Diels-Alder反应研究

Pentaerythritol supported imidazolidin-4-one catalyst for enantioselective Diels-Alder reactions

将高效小分子催化剂手性咪唑烷-4-酮支载到季戊四醇上制得季戊四醇支载手性咪唑啉酮,并将其应用于催化不对称Diels-Alder反应.新型的催化剂表现出良好的催化活性,且可以通过沉淀、过滤的方式回收,循环使用4次催化活性未见明显下降.

Highly efficient and enantioselective organocatalyst, imidazolin-4-one, has been successfully immobilized on pentaerythritol and it has been applied in enantioselective Diels-Alder reactions. The novel catalyst demonstrated excellent catalytic performance for Diels-Alder reactions and can be recovered by simple precipitation and filtration,and recycled for up to four runs without obvious decrease in catalytic activity.