滋阴清嗓汤对咳嗽变异性哮喘发作期患儿的辅助治疗效果

Adjuvant treatment of children cough variant asthma in acute stage with Ziyin Qingsang Decoction

目的探讨中医方剂滋阴清嗓汤(北沙参、麦冬、芦根等)辅助常规西医疗法治疗咳嗽变异性哮喘发作期患儿的临床效果及细胞因子影响分析。方法选取我校附属医院儿科收治的108例咳嗽变异性哮喘患儿,采用随机数字表法分为中医组和常规组各54例,两组患儿均给予氯雷他定、氨茶碱和普米克令舒治疗,中医组加用滋阴清嗓汤治疗,观察两组患儿的治疗效果差异。结果治疗后中医组患儿的咳嗽减轻时间、咳嗽消退时间、夜咳停止时间均显著的短于常规组患儿(P<0.05,P<0.01);中医组的嗜酸性粒细胞阳离子蛋白(ECP)、血清免疫球蛋白(Ig E)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)水平显著低于常规组患儿(P<0.05);咳嗽、咽干咽痒、胸闷气急、咳痰及中医证候总分,中医组显著低于常规组患儿(P<0.05);中医组患儿的治疗愈显率92.59%,显著高于常规组患儿的76.93%(P<0.05)。结论滋阴清嗓汤辅助疗法治疗咳嗽变异性哮喘发作期患儿效果显著优于单纯西医疗法。

AIM To treat the cough variant asthma（CVA） in acute stage in children with conventional chemical medicines combined with Ziyin Qingsang Decoction（Glehniae Radix,Ophiopogonis Radix,Phragmitis Rhizoma,etc.） and to investigate the effect of cytokines.METHODS One hundred and eight cases of pediatric patients with CVA in our hospital were randomly divided into herb group and control group,with 54 cases in each group.Two groups were given medicines（loratadine,aminophylline,and pulmicort respules）,herb group added with Ziyin Qingsang Decoction.Therapeutic effect differences between the two groups were observed.RESULTS Data after the treatment showed that the cough reduced time,the cough disappeared time,and night cough stopping time in herb group were significantly shorter than those of the control group（P〈0.05,P〈0.01）;The levels of eosinophil cationic protein（ECP）,IL-4,and IL-5 were significantly lower than those of the control group（P〈0.05）;the indices,such as cough,throat itching,chest tightness,shortness of breath,sputum and TCM syndrome score in herb group were markedly lower than those of the control group（P〈0.05）;The former with a effective rate of 92.59% which was significantly higher than that of the latter with 76.93%（P〈0.05）.CONCLUSION Ziyin Qingsang Decoction plays an auxiliary role in treating cough variant asthma.Combined therapy is better than chemical medicine therapy alone.