强化乳铁蛋白配方奶粉对婴儿体格及红细胞指数的影响

A study on the effect of lactoferrin fortified formula milk on growth and blood erythrocyte indices among infants

目的评价乳铁蛋白（LF）强化配方奶粉对婴儿生长发育和红细胞指数的影响。方法采用前瞻性多中心对照干预的实验设计,筛选后予以人乳喂养4-6月龄健康足月儿,按门诊顺序分别纳入强化组和对照组,干预3个月。期间两组婴儿分别进行体格指标和血生化指标检测。结果 213名婴儿完成研究,其中强化组115人,对照组98人。干预3个月后强化组和对照组婴儿体重分别为（8 723±245）和（8 558±214）g（P〈0.05）;年龄别体重Z评分（WAZ）分别为1.02±0.31和0.44±0.18（P〈0.05）;身高别体重Z评分（WHZ）分别为0.98±0.31和0.41±0.12（P〈0.05）;血红蛋白为（125.5±15.4）和（116.9±13.1）g/L（P〈0.05）;血清铁蛋白为（44.7±17.2）和（31.6±18.4）μg/L（P〈0.05）;同时,干预后强化组贫血和铁缺乏检出率分别为4.35%和13.91%,均明显低于对照组的7.14%和24.49%（P〈0.05）。结论添加强化LF配方奶粉干预可以改善人乳喂养婴儿生长发育以及铁营养状况。

Objective To explore the effect of lactoferrin fortified formula milk on growth and blood erythrocyte indicesamong infants. Methods In this prospective multi - center controlled intervention study, a total of 260 infants wereselected from six maternal and children s health care hospitals in the area. All subjects were divided into two sequence of outpatient ： lactoferrin fortified formula milk group （ fortified group, FG,containing lactoferrin 38 mg/100 g milk and iron element 4mg/100 g milk） and no lactoferrin fortified milk （ control group, CG,containing lactoferrin 0 mg/100 g milk and iron element 4. 2 mg/100 g milk） for 3 months. The levels of weight, heigand the concentration of hemoglobin （ Hb）, serum ferritin （ SF ）,red blood cell count （ RBC ）,hematocrit （ Hct ） ,mean corpuscular volume （ MCV ）,mean corpuscular hemoglobin （ MCH）, mean corpuscular hemoglobin concentration（MCHC）,red blood cells volume distribution width （RDW） and HAZ,WAZand WHZwere recorded before and after intervention,respectively. Results A total of 213 （including 115 in FG, and 98 in CG） infants were included in the mtervention trial and all measurement of biochemical indicators were detected. There were no significant difference in theaverage amount of daily intake of formula milk （94. 3 ± 9. 8 g vs. 88. 2 ± 8. 7 g for FG and CG,P 〉 0. 05 ） and iron element （3.8 ±0.4 mg vs. 3. 7 ± 0. 6 mg for FGand CG,P 〉0. 05） . The average amount of daily intake of lactoferrin for infants in FGgroup was 35. 8 ±3.7 mg. The level of weight,WAZ,WHZ,Hb,SF,MCV and MCHC of infants in FGafter intervention were all significantly higher than those of infants in CG [weight,（ 8773 ± 245 ） g vs. （ 8558 ± 214 ） g; WAZ,（ 1.02 ± 0 .3 1 ） vs. （0 .4 4 ±0.18 ）; WHZ,（ 0 .9 8 ± 0 .3 1 ） vs. （0 .4 1 ± 0 .1 2 ）; Hb,（ 125.5 ± 1 5 .4 ） g/L , vs. （116.9±13.1） g/L; SF,（ 4 4 .7 ± 1 7 .2 ） μg/L vs. （ 3 1 .6 ± 1 8 .4 ） but significantly lower for the prevalence of anemia （4.35% vs. 7.14%） and iron deficiency （13. 91 % vs. 24.49%） （P〈0.05）. Conclusion The intervention of lactoferrin fortified formula milk presented significant effects on iron metabolic homeostasis and erythrocyte indices of infant with breastfeeding.