小檗碱对糖耐量异常患者血管形态改变的临床观察

Clinical observation on effects of berberine on vascular morphology transform in impaired glucose tolerance patients

目的:探讨小檗碱对糖耐量异常患者双侧颈内动脉管腔直径及内膜厚度变化的影响。方法:同期入选经OGTT实验明确符合糖耐量异常诊断的患者80例,按就诊单双号随机将所有患者分为小檗碱试验组(A组)和对照组(B组)各40例,对照组给予阿卡波糖,同期试验组在对照组的基础上应用小檗碱干预,随诊用药半年,试验前后测量所有糖耐量异常患者双侧颈内动脉管腔直径及内膜厚度,并对试验组和对照组患者颈内动脉血管形态变化进行对比。结果:与试验前对比,试验组患者双侧颈内动脉血管内膜厚度减小,管腔直径变宽,对照组无明显变化;试验组与对照组比较,干预前后患者血管形态改变的差异有统计学意义(P<0.05)。结论:糖耐量异常属中医"消渴"范畴,以阴虚燥热为基本病机,"消渴方"在中医中药辨证论治中应用黄连清热降火,取其小檗碱能稳定血糖,防止血管内膜增厚、扩张血管之效用,从而改善血管形态。

Objective： To explore effects of berberine on bilateral internal carotid artery plus intima-thickness in patients with abnormal glucose tolerance. Methods： 80 patients were randomly divided into the experimental group （group A） and control group （group B）. In the control group, 40 patients were given acarbose; and in the experimental group, 40 patients took berberine more. Results： Compared with before, in the group A, bilateral internal carotid and artery intima thickness were decreased; and lumen diameter were widened. In the control group, there was no signiifcant change; compared with the control group, vascular morphological changes before and after the intervention was statistically signiifcant difference （P〈0.05）. Conclusion： Berberine can stable blood glucose, prevent from vascular intimal thickening and dilating blood vessels, improve blood vessels.