动脉自旋标记灌注成像在缺血性脑血管病中的应用价值(附50例分析)

Application of arterial spin labeling perfusion imaging in ischemic cerebrovascular diseases(50 cases of analysis)

目的探讨动脉自旋标记灌注成像(arterial spin labeling,ASL)在缺血性脑血管病中的应用价值。方法选取我院收治入院的缺血性脑血管病患者50例,均行磁共振成像(magnetic resonance imaging,MRI)、磁共振扩散加权成像(diffusion weighted imaging,DWI)、动态磁敏感对比增强技术(dynamic susceptibility contrast,DSC)、三维动脉自旋标记灌注成像(average search length,ASL)检查,对比不同检查方法的阳性检出率、缺血半暗带面积,在ASL上对比不同部位脑血流量值(cerebral blood flow,CBF)与对侧正常区CBF值。结果 ASL与DWI的阳性检出率均为100.0%,与常规MRI扫描(72.0%)相比,差异有统计学意义(P<0.05);DSC、ASL两种检查方法的缺血半暗带面积对比差异无统计学意义(t=2.011,P=0.082);ASL检查下男性患者与女性患者各病变部位的CBF值对比无统计学差异(P>0.05),与对侧正常区相比,明显偏低,存在统计学差异(P<0.05)。结论 ASL在缺血性脑血管病病灶检出及血流灌注提示方面的应用价值较高,值得进一步推广使用。

Objective To study the application value of arterial spin labeling （ASL） perfusion imaging in ischemic cerebrovascular disease. Methods June 2013-May 2013, 50 inpatients of our hospital with ischemic cerebrovascular disease received magnetic resonance imaging （MRI）, diffusion weighted imaging （DWI）, dynamic susceptibility contrast （DSC）, and ASL examination. Positive detection rate of different inspection methods, area of ischemia and half dark, CBF value of different parts and contralateral normal area on ASL were contrasted. Results Positive detection rates of ASL and DWI were 100.0%, and compared with conventional MRI scan （72.0%）, the difference was statistically significant （7.2 = 10. 337, P= 0. 029; 72 13. 448, P=0. 016）. Two and a half dark zone area of DSC and ASL had no statistical difference （t=2. 011, P=2. 011）. CBF value of every diseased region between male and female on ASL had no statistical difference （P〉0.05）, compared with the contralateral normal area, it was obviously lower, and there was statistical difference （P〈0.05）. Conclusion ASL has high applied value on detection of focus and prompt of blood flow perfusion in ischemic cerebrovascular disease, and it is worth further application.