维持性血液透析患者微炎症状态对机体的影响

Influence of the Microinflammation on the Body of Patients with Maintenance Hemodialysis

目的:探讨维持性血液透析患者微炎症状态对机体的影响。方法:根据诊断标准纳入90例患者,以C-反应蛋白(CRP)作为微炎症的标记物,分为微炎症组(透前CRP≥8 mg·L^(-1))和正常组(透前CRP<8 mg·L^(-1))各45例,进行临床对照,检测两组患者中医证候积分,微炎症及氧化应激指标、血肌酐、血尿素氮、血红蛋白、血清白蛋白水平,总结微炎症及氧化应激状态下对患者实验室检查的干预。结果:MHD微炎症状态患者透析后中医证候积分加重(P<0.05),与正常组比较有统计学差异(P<0.05)。C-反应蛋白、肿瘤坏死因子-α、白细胞介素、脂蛋白、白蛋白、MDA及AOPP高于正常组(P<0.05);SOD、血肌酐、尿素氮、血红蛋白均低于正常组(P<0.05)。结论:维持性血液透析患者炎性因子及氧化应激状态下严重影响患者的临床症状与病情预后,应给予足够重视。

Objective： To explore the influence of microinflammation on the body of patients with maintenance hemodialysis（ MHD）. Methods： Totally 90 patients in accordance with the diagnostic criteria took CRP as the microinflammation marker and were randomized into microinflammation group（ CRP≥8 mg / L before hemodialysis） and normal group（ CRP 〈 8 mg / L before hemodialysis）,with 45 cases in each group. The TCM symptom scores,microinflammation and oxidative stress indicators,serum creatinine,blood urea nitrogen,hemoglobin,serum albumin levels in both groups were determined and compared between the two groups. Results： The TCM score of MHD microinflammation of patients increased after hemodialysis（ P 〈 0. 05）; there is statistical significance compared with normal group（ P 〈 0. 05）. The levels of CRP,rumor necrosis factor-α,interleukin,lipoprotein,albumin,MDA and AOPP were higher than these in normal group（ P 〈 0. 05）. The level of SOD,serum creatinine,blood urea nitrogen,hemoglobin,serum albumin in microinflammation group were all lower than these in normal group（ P 〈 0. 05）. Conclusion： The inflammation factors of the MHD patients and the oxidative stress state seriously influence the clinical symptoms and prognosis of the patients,which should be attached enough importance to.