轻型颅脑损伤患者血清泛素C末端水解酶L1水平变化情况分析

Analysis on dynamic changes of serum ubiquitin C-terminal hydrolase L1 in patients with mild head injury

目的分析血清泛素C末端水解酶L1(UCH-L1)水平在轻型颅脑损伤中的意义及同预后的关系。方法选取2014年8月到2015年7月东莞市塘厦医院收治的30例轻型颅脑损伤患者作为观察组,根据头颅CT阴性和阳性分为A、B两组;同时取30例健康体检者为对照组,用ELISA方法检测患者血清UCH-L1水平,分析患者轻型颅脑损伤程度与UCH-L1水平的关系,并评估患者预后质量。结果对照组血清UCH-L1水平明显低于观察A、B两组,差异有统计学意义(P<0.05);观察A组患者血清UCH-L1水平明显低于观察B组,差异有统计学意义(P<0.05);观察A组患者GOS评分低于观察B组,差异有统计学意义(P<0.05)。结论血清UCH-L1可以作为鉴别轻型颅脑损伤的生物标志物,对患者预后质量的判断具有一定的参考价值。

Objective To analyze the significance of serum ubiquitin C -terminal hydrolase L1 （UCH -L1）in patients with mild head injury and its relationship with the prognosis quality.Methods 30 patients with mild head injury treated in Tangxia Hospital of Dongguan from August of 2014 to July of 2015 were selected as the observation group.They were divided into group A and group B according to the negative and positive head CT results.30 healthy subjects with physical examination were took as the control group.The level of serum UCH -L1 was detected by ELISA method.The relationship between GOS -E scores and UCH -L1 level was analyzed,and the prognosis of patients were assessed.Results UCH -L1 level of the control group was significantly lower than that of the observation group （both A and B）,and the difference was statistically significant （P 〈0.05）. UCH -L1 level of group A was significantly lower than that of group B,and the difference was statistically significant （P 〈0.05）.GOS scores of goup A were lower than group B,and the difference was statistically significant （P 〈0.05 ）. Conclusion Serum UCH -L1 can be used as a biomarker for the identification of mild brain injury,and it has a certain refer-ence value for the prognosis of patients.