2型糖尿病幽门螺旋杆菌感染临床观察

Clinical observation on helicobacter pylori infection in type 2 diabetes mellitus

目的观察2型糖尿病幽门螺旋杆菌(Helicobacter pylori,Hp)感染状况。方法选取2014年8月到2015年9月在本院体检中心健康体检者100例即健康体检组,选取于我院内科门诊和病房符合1999年美国糖尿病协会诊断标准的2型糖尿病患者100例即2型糖尿病组,分别采用^(13)C-尿素呼气试验检出两组Hp感染阳性者并予以抗Hp四联治疗10d,停药6周后复测^(13)C-尿素呼气试验,随访6个月。比较两组间Hp感染率、抗Hp治疗根除率以及Hp根除后复发率。另将2型糖尿病组Hp阳性者根据治疗结果筛选出根除Hp未复发和未根除(包括复发者)Hp2个亚组,分别监测亚组间患者Hp根除前后糖化血红蛋白。结果健康体检组Hp感染率47.0%、根除率85.1%、复发率7.5%,2型糖尿病组Hp感染率61.0%、根除率67.2%、复发率12.2%,两组间Hp感染率、根除率比较差异具有统计学意义,复发率差异无统计学意义。根除Hp未复发组的患者前后糖化血红蛋白的差值变化具有统计学意义,而未根除Hp组前后糖化血红蛋白的差值变化无明显差异。结论 2型糖尿病人群Hp感染率高、根除率低,根除Hp感染有利于血糖控制。2型糖尿病与Hp感染存在一定的关系。

Objective To investigate the correlation between the infection of helicobacter pylon（HP） in type 2 diabetes mellitus.Methods 100 cases of healthy people were randomly selected in the examination center of our hospital from August 2014 to September 2015 for health examination group.100 cases of type 2 diabetic patients were selected in department of internal medicine clinicaccording todiagnostic criteria of American Diabetes Association of 1999 for type 2diabetic patient group.These people were supervised with their Hp~＋infection rate by^（13）C urea breathing test,and then conducted with anti-Hp quadruple therapy for 10 days.The ^（13）C urea breath test were conducted again for six weeks after stopping the medicine.Following up for 6 months the inflection rate of HP,the radical cure rate of anti-HP and the recurrence rate of HP after a radical cure were compared,between two groups.The Hp-positive patients in type 2 diabetic patient group separated into two subgroups that were Hp eradication success without recurrence and Hp eradication fail.The glycosylated hemoglobin of two subgroups were supervised before and after HP eradication.Results For health examination group,Hp infection rate was47.0%,eradication rate 85.1%,recurrence rate 7.5%.For type 2 diabetic patient group Hp infection rate was 61.0%,eradication rate 67.2%,and recurrence rate 12.2%.Comparative differences of infection rate and eradication rate between two groups hasstatistical significance.The recurrence rate between two groups has no statistical differences.There is no remarkable difference between the glycosylated hemoglobin before and after Hp eradication treatment for the diabetic patient that didnt eradicate HP,while the diabetic patients who has eradicate Hp without recurrence have significantly different glycosylated hemoglobin before and after the treatment.Conclusion For type 2 diabetic patients,the Hp infection rate is higher,and the eradication rate is lower.It＇s helpful to control theglycosylated hemoglobin after the eradication of Hp.Helicobacter pylori infection and type 2 diabetes mellitus have correlation.