EPO对HIE患儿血清MBP NSE水平的影响

The effects of erythropoietin on serum MBP and NSE in neonates with hypoxic-ischemic encephalopathy

目的通过探讨促红细胞生成素(erythropoietin,EPO)对新生儿缺氧缺血性脑病患儿(Hypoxic-ischemic Encephalopathy,HIE)血清髓鞘碱性蛋白(myelin basic protein,MBP)及神经元特异性烯醇化酶蛋白(neuron-specific enolase,NSE)水平的影响,从而评估其神经保护作用。方法 HIE患儿40例随机分为常规治疗组20例、EPO治疗组20例,常规治疗组予以控制惊厥、降颅压、消除脑干症状;维持良好的通气、维持各脏器血流等对症支持治疗;EPO治疗在常规治疗组的基础上予以EPO200IU/kg·d肌肉注射,治疗9d,检测并比较2组血清MBP及NSE蛋白水平。结果治疗前HIE患儿2组之间血清中NSE、MBP差异无统计学意义(tNSE=1.069,P^(NSE)=0.312;t_(MBP)=1.143,P_(MBP)=0.217)。治疗后EPO治疗组血清中NSE、MBP水平低于常规治疗组,差异有统计学意义(t_(NSE)=2.21,P_(NSE)=0.028;t_(MBP)=2.14,PMBP=0.033)。结论 EPO可降低HIE患儿血清MBP及NSE的水平,对修复神经细胞具有一定的作用。

Objective To study the effects of erythropoietin on serum myelin basic protein（MBP） and neuron-specific enolase（NSE） in neonates with hypoxic-ischemic encephalopathy,and then determine the neuroprotective efficacy of EPO.Methods Forty neonates with HIE were randomly divided into conventional treatment（n =20） and EPO treatment groups（n =20）.The conventional treatment in infants with HIE were given the therapy of anti-convulsions,decreasing intracranial pressure,eliminating the symptoms of brain stem,maintaining a good function of ventilation and the blood flow of the organ.EPO 200 U /kg per day were given in conjunction with the conventional treatment was well tolerated.On the ninth day after treatment,the concentration of NSE and MBP in serum were measured.Results It was not significant differences in the levels of NSE and MBP between the conventional treatment and EPO treatment groups（t=1.069,1,143,P=0.312,0.217）.On the ninth day after treatment,the serum NSE and MBP levels were significantly lower in the EPO treatment group than in the conventional treatment group（t =2.21,2.14,P=0.028,0.033）.Conclusion It may be conclusion that EPO has the function of neural repair by dynamic monitoring of serum NSE and MBP levels.