期刊文献+

The role of postsynaptic density proteins in neural degeneration and regeneration

The role of postsynaptic density proteins in neural degeneration and regeneration
下载PDF
导出
摘要 The structure,function and plasticity of excitatory glutamatergic synapses in the brain are significantly altered by neurodevelopmental and neurodegenerative disorders(Grabrucker et al.,2011;Fourie et al.,2014;Musardo et al.,2014;Lee et al.,2015),resulting in impairments in cognition,learning,memory,motor and sensory function. The structure,function and plasticity of excitatory glutamatergic synapses in the brain are significantly altered by neurodevelopmental and neurodegenerative disorders(Grabrucker et al.,2011;Fourie et al.,2014;Musardo et al.,2014;Lee et al.,2015),resulting in impairments in cognition,learning,memory,motor and sensory function.
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第6期906-907,共2页 中国神经再生研究(英文版)
关键词 degeneration regeneration synaptic sensory altered glutamate excitatory plasticity neurological NMDA degeneration regeneration synaptic sensory altered glutamate excitatory plasticity neurological NMDA
  • 相关文献

参考文献12

  • 1Arons M, Thynne CJ, Grabrucker AM, Li D, Schoen M, Cheyne JE, Boeckers TM, Montgomery JM, Garner CC (2012) Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-ruediated transsynaptic signaling. J Neurosci 32: 14966-14978.
  • 2Fourie C, Kim H, Waldvogel H, Wong JM, McGregor A, Faull RLM, Montgomery JM (2014) Differential changes in postsynaptic density proteins in postmortem Huntington's disease and Parkinson's disease human brains. J Neurodegen Dis 2014:938530.
  • 3Gardoni F, Sgobio C, Pcndolino Y, CaJabresi O, Di Luca M, Picconi B (2012) Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias. Neurobiol Aging 33:2138-2144.
  • 4Grabrucker AM, Schmeisser MJ, Udvardi PT, Arons M, Schoen M, Woodling NS, Andreasson KI, Hof PR, Buxbaum JD, Garner CC, Boeckers IM (2011) Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Mol Neurodegen 6:65.
  • 5Lee E), Lee H, Huang TN, Chung C, Shin W, Kim K, Koh JY, Hsueh YP, Kim E (2015) Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation. Nat Commun 18:7168.
  • 6Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM (2011) SAP97 directs NMDA receptor spine targeting and synaptic plasticity. J PhysioI589:4491-4510.
  • 7Lim S, Naisbitt S, Yoon J, Hwang Jl, Suh PG, Sheng M, Kim E (1999) Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. J Bioi Chem 274:29510-29518.
  • 8MacGiUavry HD, Song Y, Raghavachari S, Blanpied TA (2013) Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors. Neuron 78:615-622.
  • 9Mei Y, Monteiro P, Zhou Y, Kim J, Gao X, Fu Z, Feng G (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature 530:481-484.
  • 10Montgomery JM, Zamorano PL, Garner CC (2004) MAGUKs in synapse assembly and function: an emerging view. Cell Mol Life Sci 61 :911-929.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部