ADAM10、ADAM17的作用和miRNA的调节在腹主动脉瘤发病机制中的研究进展

Actions of ADAM10 and ADAM17 and regulatory role of mi RNAs in pathogenesis of abdominal aortic aneurysm

腹主动脉瘤(AAA)是一种病死率极高的急症,因发病机制复杂,至今病因尚未明确。近年来研究发现,去整合素和金属蛋白酶(ADAM)家族参与促进炎性因子的释放、细胞外基质降解等特性可能与AAA发病有关;mi RNA在血管平滑肌细胞中特异性表达并通过信号通路调节其增殖和凋亡、靶向调控炎性细胞分化和炎性因子的释放、调节细胞外基质蛋白表达等可能也参与调节AAA发病。笔者就ADAM10和ADAM17在AAA发病机制中作用和mi RNA对AAA发病调节做一综述。

Abdominal aortic aneurysm （AAA） is an urgent clinical condition with high mortality, and its pathogenesis is complicated and has not been elucidated so far. Recent investigations found that the features of participation of a disintegrin and metalloprotease （ADAM） family in inflammatory factor release and degradation of extracellular matrix suggest their involvement in the onset of AAA;miRNAs may also play regulatory roles in occurrence of AAA, because of their speciifc expression in vascular smooth muscle cells （VSMCs）, regulating the proliferation and apoptosis of the VSMCs through the signaling pathways, targeted regulation of inlfammatory cell differentiation and the release of inlfammatory cytokines, and regulating extracelluar matrix protein expressions. hTe authors, in this paper, address the actions of ADAM10 and ADAM17 in AAA and the regulatory mechanisms of miRNAs in the pathogenesis of AAA.