当归四逆汤对雷诺病患者血小板5-羟色胺水平的影响

The Effect of Danggui Sini Decoction on Platelets 5-HT for the Patients Suffer from Raynaud's Disease

目的观察当归四逆汤治疗雷诺病的临床效果及治疗前后患者5-羟色胺(5-HT)水平的改变情况。方法将符合雷诺氏病患者60例随机分成两组,试验组(n=30)内服当归四逆汤,对照组(n=30)口服硝苯地平缓释片,疗程均为4周。比较两组的临床疗效,同时检测试验组治疗前后患者血小板5-HT水平。结果试验组总有效率93.33%,对照组总有效率56.67%,两组比较差异有统计学意义(P<0.01)。试验组治疗前血小板5-HT水平(47.2±4.2)nmol/109血小板,试验组治疗后血小板5-HT水平(40.5±4.0)nmol/109血小板。试验组治疗前后血小板5-HT差异有统计学意义(P<0.05)。结论当归四逆汤治疗雷诺病疗效显著,明显优于硝苯地平。且先降低患者血小板5-HT水平。

Objective To explore the effect of danggui sini decoction on Platelets 5-HT for the patients suffer from Raynaud＇s disease. Methods Sixty patients of Raynaud＇s disease were randomly divided into group A（n = 30） and B（ n = 30）. Based on comprehensive treatment, the patients in group A were given danggui sini decoction, while those in group B were given nifedipine. After treatment 4 weeks, compare the clinical effect between group A and group B. Meanwhile, compare Platelets 5-HT in group A before treatment and four weeks after treatment. Results 4 weeks after treatment, the clinical efficient of group A is group B （P 〈 0. 01 ）, and the core of 5-HT in group A is lower than treatment before （P 〈 0. 05 ）. Conclusion Danggui sini decoction is more effective than nifedipine to cure the patients of Raynaud＇s disease. Meanwhile, danggui sini decoction decrease the core of Platelets 5-HT on the patients of Raynaud＇s disease.