局部应用米诺环素软膏与局部应用甲硝唑凝胶治疗牙周炎的疗效对比分析

Comparative Analysis of Therapeutic Effect of Topical Application of Minocycline Ointment and Metronidazole Gel in Treating Parodontitis

目的对比米诺环素与甲硝唑凝胶局部治疗牙周炎的疗效。方法将我院口腔科门诊2012年7月至2013年7月收治的126例慢性牙周炎患者按治疗方案随机分为两组,观察组(n=63)采用米诺环素治疗,对照组(n=63)采用甲硝唑凝胶局部治疗。治疗1个月后比较龈沟出血指数(SBI)、牙龈指数(GI)菌斑指数(PLI)及牙周袋探诊指数(PD),两组患者治疗的有效率以及不良反应情况。结果治疗后,观察组患者的牙周指标较对照组有明显降低,差异有统计学意义(P<0.05);观察组总不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论米诺环素用于牙周炎的治疗具有有效率高,能显著改善患者的临床症状,不良反应少的优点,较甲硝唑凝胶局部治疗有更好的综合效应,值得推广。

Objective To compare the therapeutic effect of minocycline ointment in treating parodontitis and the effect of metronidazole gel in treating parodontitis topically. Methods Randomly divided the 126 patients with chronic periodontitis who were treated by stomatology clinic of our hospital from July,2013 to July,2014 into two groups based on therapeutic prescription, patients in the observation group（n = 63）toke minocyeline,those in the control group toke metronidazole gel topically. After treat- ment for a month, compared sulcus bleeding index （SBI） , gingival index （GI） , plaque index （PLI） , periodontal pocket probing in- dex （PD） ,therapeutic efficiency and adverse drug reactions between the two groups. Results After treatment, periodontal index of the observation group was obviously lower than that of the control group,the difference was statistically significant（ P 〈 O. 05 ） ;The overall incidence of adverse drug reactions was obviously lower than that of the control group ,the difference was statistically signifi- cant（P 〈 0. 05）. Conclusion Minocyeline has a high efficiency in treatment of parodontitis, it can significantly improve the patients＇ symptoms,and has fewer adverse reactions. The comprehensive effect is better than metronidazole gel in treating parodonti- tis topically and is worth spreading.