抗菌肽LL-37在银屑病发病机制中的作用

AntimicrobialPeptides LL-37 in the Immunopathogenesis of Psoriasis

银屑病是一种以T淋巴细胞异常活化和浸润为主要特征的慢性炎性反应皮肤病。抗菌肽LL-37的表达在银屑病的发病机制中可能处于上游地位,并成为新的治疗靶标。LL-37过度表达可导致浆细胞样树突状细胞异常活化,并激活Th1,Th17细胞与角质形成细胞间的循环刺激网络,是银屑病皮损炎症反应持续存在的重要基础。

Psoriasis is a chronic inflammatory skin disease characterized by abnormal activated T cells infiltration. Recently, LL-37 has been recognized as an upper position and potential therapeutic target in psoriasis. Overexpression of LL- 37 in psoriasis leads to abnormal activation of plasmacytoid dendritic cells and the formation of stimulation loop between Th cells （ Thl and Th17 cells） and kerotinocyte. This is one of important foundations of persist out inflammation in psoriasis lesions.