摘要
目的:优选活血巴布膏的成型工艺,为制备符合临床需要的巴布膏奠定基础。方法:以黏附性、外观均匀性、膜残留性、皮肤追随性、揭帖性与基质残留、涂展性等的综合评分为因变量,在单因素试验基础上,采用星点设计-效应面法考察聚丙烯酸钠-700,甘油,甘羟铝及聚维酮K-90用量对活血巴布膏成型工艺的影响。结果:活血巴布膏基质最佳配比聚丙烯酸钠-700-聚乙烯醇-甘油-甘羟铝-聚维酮K-90-微粉硅胶-水-药膏为4.7∶0.5∶29.2∶0.5∶3∶4∶22.4∶12.9。制备的活血巴布膏易于涂布、膏面光洁、色泽一致、禙衬平整无渗漏、皮肤追随性及初黏力良好、揭贴无痛感、无残留。结论:优选的成型工艺科学合理、稳定可行,为活血巴布膏的开发提供参考。
Objective: To optimize preparation process of Huoxue cataplasm. Method: Taking composite score of adhesion,appearance uniformity,film residue,skin compliance,spreadability and others as index,based on single factor tests,central composite design-response surface methodology was used to optimize preparation process with amounts of sodium polyacrylate-700,glycerin,aluminium glycinate and povidone K-90 as factors. Result: Optimum substrate composition was sodium polyacrylate-700 / polyvinyl / glycerin / aluminium glycinate / povidone K-90 / aerosil / water / ointment was 4. 7 ∶ 0. 5 ∶ 29. 2 ∶ 0. 5 ∶ 3 ∶ 4 ∶ 22. 4 ∶ 12. 9. Cataplasm was coated easily with smooth cream surface,consistent color,good skin followability and no leakage. Conclusion: This preparation process is rational and suitable for production of Huoxue cataplasm.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第13期19-22,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山东省自主创新成果转化重大专项(2012ZHZX1C0405)