血管内皮生长因子联合内皮抑素在2型糖尿病肾病患者诊断中的价值分析

Analysis value of vascular endothelial growth factor endostatin in patients diagnosed with type 2 diabetic nephropathy

目的探讨血管内皮生长因子(VEGF)联合内皮抑素(ES)在2型糖尿病肾病诊断中的价值。方法该院2012年4月至2014年9月收治的30例糖尿病患者和60例糖尿病肾病患者按照患者病情分为无肾病组(30例)、肾病组(低蛋白尿组30例和高蛋白尿组30例)。比较无肾病组、低蛋白尿组、高蛋白尿组患者的VEGF和ES水平,并进行相关分析。结果无肾病组、低蛋白尿组、高蛋白尿组患者VEGF和ES水平进行比较,差异有统计学意义(P<0.05),低蛋白尿组和高蛋白尿组的VEGF和ES均比无肾病组高(P<0.05),且高蛋白尿组VEGF和ES水平高于低蛋白尿组(P<0.05);进行回归性分析结果显示,VEGF和ES与2型糖尿病肾病相关;VEGF和ES与患者的肾小球滤过率和清蛋白呈负相关,与患者的24h尿液中微量清蛋白和视网膜病变呈正相关。结论血浆内VEGF和ES在2型糖尿病不同临床分期有不同程度的升高,对糖尿病患者进行VEGF和ES检测可以及时发现并发肾病的危险。

Objective To explore the value of vascular endothelial growth（VEGF）and endostatin（ES）on diagnosing type 2diabetic nephropathy.Methods 30 patients with diabetes and 60 patients with diabetic nephropathy were selected in our hospital from April 2012 to September 2014,and according to the patient′s condition,these objects were divided as non-nephropathy group（30cases）,kidney disease group（30cases were in low proteinuria group,30 patients were in high proteinuria group）.General information,biochemical markers of endothelial growth factor and ES in non-nephropathy group,low proteinuria group and high proteinuria group were compared and conducted correlation analysis.Results There were significant differences on VEGF and ES levels in the three groups（P〈0.05）,the VEGF and ES levels in high proteinuria group and low proteinuria group were significant higher than those of the non-nephropathy group（P〈0.05）,and those in high proteinuria group were significant higher than those of the low proteinuria group（P〈0.05）.Regression analysis showed that the VEGF and ES were correlated with type 2diabetic nephropathy.The VEGF and ES were negatively correlated with glomerular filtration rate and albumin,and positively correlated with retinopathy.Conclusion VEGF and ES in different clinical stages of type 2diabetes increase in varying degrees,VEGF and ES detection have value in the diagnosis of nephropathy in type 2diabetes.