妊娠期甲状腺自身抗体检测对糖尿病产妇甲状腺功能评估的价值

Value of monitoring thyroid auto-antibodies in thyroid function assessment for pregnant women with gestational diabetes mellitus

目的探讨检测妊娠期甲状腺自身抗体对妊娠期糖尿病（GDM）产妇甲状腺功能的评估价值。方法选择2014年2~8月在该院确诊为GDM的产妇140例纳入观察组,80例健康产妇纳入对照组。检测促甲状腺素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、抗甲状腺球蛋白抗体（TGAb）和抗甲状腺过氧化物酶抗体（TPOAb）。结果两组产妇TSH、T3、T4、FT3水平相比,差异无统计学意义（P〉0.05）;观察组FT4水平低于对照组,差异有统计学意义（P〈0.05）;观察组TGAb、TPOAb及二者联合检测阳性率均明显高于对照组,差异有统计学意义（P〈0.05）。结论甲状腺抗体检测对GDM产妇甲状腺功能评价具有重要作用,能及时发现甲状腺病变,有利于改善妊娠结局。

Objective Explore value of detecting thyroid auto-antibodies level in thyroid function assessment for pregnant women with gestational diabetes mellitus（GDM）.Methods A total of 140 patients with GDM in Bridge Hospital of Panyu District from February to August in 2014 were selected as the observation group,80 healthy pregnant women were selected as control group.Thyroid stimulating hormone（TSH）,three iodine thyroid glycine（T3）,thyroxine（T4）,three free iodine thyroid former glycine（FT3）and free thyroxine（FT4）,anti thyroglobulin antibody（TGAb）and thyroid peroxidase antibody（TPOAb）of different groups were detected by Chemiluminescence method and compared.Results The differences of TSH,T3,T4,FT3 were not statistically significant between the two groups（P〉0.05）,FT4 levels in the observation group was significant lower than that of the control group（P〈0.05）,the positive rates of TGAb,TPOAb and combined detection in the observation group were significant higher than those of the control group（P〈0.05）.Conclusion Detection of thyroid auto-antibody has an important role in the evaluation of thyroid function for GDM women,could diagnosis thyroid disease early,and be beneficial to improving pregnancy outcomes.