双相障碍患者脑灰质体积变化性别差异性研究

Gender Differences of Gray Matter Abnormalities in Patients with Bipolar Disorder

目的:寻找不同性别双相障碍患者灰质体积减少脑区差异,探讨不同性别患者临床表现差异性的病理学机制。方法:以26位女性正常人、26例女性双相障碍患者、25位男性正常人、24例男性双相障碍患者作为研究对象,匹配年龄、受教育程度等。进行头部结构磁共振扫描,对平滑后的灰质图像进行双样本t检验,分析不同性别双相障碍患者灰质体积减少的脑区。结果:与女性对照组相比,女性双相障碍患者右侧舌回、右侧楔叶、右侧枕中回、右侧扣带回后部、右侧中央前后回脑区体积下降。与男性对照组相比,男性双相障碍患者体积下降的脑区包括右侧颞上回、右侧颞中回、右侧海马旁回、右侧额中回、右侧额下回、右侧楔前叶、右侧顶下小叶及右侧小脑后叶。结论:双相障碍患者体积下降脑区具有性别差异性,男性患者体积下降的脑区多在右侧颞叶皮层以及额叶及小脑后叶,而女性患者体积下降脑区多在右侧枕叶皮层以及扣带回后部及中央前后回脑区;这种差别可能与双相障碍患者临床表现的性别差异有关。

Objective： To study the brain regions of reduced gray matter volume of the different sexual patients with bi- polar disorder. Methods： Twenty-five healthy male subjects, twenty-four male patients with bipolar disorder, twenty-six healthy female subjects and twenty-six female patients with bipolar disorder participated to the study. The MRI brain struc- tural images were scanned. Then two-sample t-tests were performed to investigate the brain regions of reduced gray matter volume in both female patients and male patients with bipolar disorder. Results： Compared with healthy females, female pa- tients with bipolar disorder had decreased volume in LingualR, OccipitalMid_R, Cuneus_R, Postcentral R. Compared with healthy males, male patients had decreased volume in TemporalMid_R, Temporal_Sup_R, Frontal_Mid_R, Fusi- formR, Frontal Inf Tri_R, Cerebelum 8 R, Cerebelum_10_R, Cerebelum Crusl R. And the brain areas of decreased volume in the male patients and the female patients were all on the right. Conclusion： The brain regions of decreased gray matter volume of different sexual patients with bipolar disorder has their specificity. Male patients had decreased gray mat- ter volume mainly in the temporal lobe, the frontal lobe and the cerebellum posterior lobe; Female patients had decreased gray matter volume mainly in the occipital cortex, the posterior cingulate, the precentral gyrus and the postcentral gyrus. And the brain areas of decreased volume in the male patients and the female patients had lateralization.