小剂量多巴胺联合多巴酚丁胺治疗小儿重症肺炎的临床疗效探讨

Application of small dose dopamine combined with dobutamine on children with severe pneumonia

目的探讨小剂量多巴胺联合多巴酚丁胺治疗小儿重症肺炎的临床效果。方法选取2013年2月~2014年2月在我院就诊的小儿重症肺炎患者90例为研究对象,按患儿入院时间先后分为两组各45例。对照组给予常规对症治疗,观察组在上述治疗基础上给予小剂量多巴胺联合多巴酚丁胺治疗,比较两组患儿治疗效果,并观察两组患儿临床症状改善时间、住院时间及不良反应发生情况。结果观察组治疗有效率93.3%,对照组77.8%,差异具有统计学意义（P〈0.05）。观察组患儿肺部湿啰音消失时间、肺部炎症吸收时间、呼吸困难消失时间、心率恢复正常时间、体温恢复正常时间及住院时间均低于对照组,差异均具有统计学意义（P〈0.05）。不良反应发生率观察组为8.9%,对照组为6.7%,差异无统计学意义（P〉0.05）。结论小剂量多巴胺联合多巴酚丁胺治疗小儿重症肺炎的效果显著,患儿症状改善时间明显缩短,值得临床推广。

Objective To investigate the clinical effect of small dose of dopamine and dobutamine in the treatment of pediatric severe pneumonia. Methods 90 cases of patients with severe pneumonia in February 2013~2014was admitted to our hospital on February,combined with admission time were divided into two groups.The control group（45cases）were given conventional symptomatic treatment,the observation group（45cases）was treated with a small dose of dopamine and dobutamine treatment on the basis of the above treatment,therapeutic effect of two groups were compared and statistical differences,the two groups of children with clinical symptoms improved time,adverse reaction rate difference. Results In the observation group,the total effective rate was 93.3%,the effective rate of the control group 77.8%,significant differences（P〈0.05）.The observation group with lung wet rales disappearance time,pulmonary inflammation absorption time,breathing difficulties disappear,heart rate returned to normal time,temperature recovery is often time and hospitalization time were lower than the control group,showed significant difference（P〈0.05）.Treatment of children in the observation group during adverse reactions occurred rate of 8.9%;control group with treatment of adverse reactions during the incidence of 6.7%,the difference between no significant difference（P〉0.05）. Conclusion Small dose dopamine combined with dobutamine in the treatment of children with severe pneumonia effect significantly,children with symptoms improved significantly shortened,it is worth clinical promotion.