对40Hz听觉稳态反应应用线性叠加条件的评估

An Assessment of Linear Superposition Conditions for 40 Hz Auditory Steady-State Responses

多刺激率稳态平均去卷积技术(MSAD)是一种基于线性叠加模型重建高刺激率下瞬态反应的新方法,这种模型在应用时要求刺激率的改变对稳态或瞬态反应不产生实质性影响。记录20位受试者在8组刺激率(平均约为40 Hz)下稳态反应,采用MSAD技术估计其构成的瞬态反应。通过对比以此合成稳态反应与所记录的稳态反应之间的差别,评估MSAD模型的有效性。结果发现,两者的V-Na峰峰值和V波潜伏期基本一致;在36.8和39.1 Hz刺激率下,合成稳态反应与记录稳态反应之间不存在统计学差异,在36.8 Hz下两者相对误差最小,为7.95%。上述结果表明,刺激率在适当范围内的变化对诱发反应的影响较小,MSAD计算条件成立。

Multi-rate steady-state averaging deconvolution（ MSAD） is a newly developed method to restore the transient auditory evoked-potential（ AEP） from the auditory steady-state responses（ ASSRs） based on superposition hypothesis. This method requires that the variation of stimulus rates impose no substance influence on the response so that the model is applicable and viable. In this study,we recorded eight ASSRs from 20 subjects of 40- Hz average rate（ from 27. 2 Hz to 57. 1 Hz）,from which the transient AEP can be derived by the MSAD method. The AEP was then used to synthesize the ASSRs at the same recording rates. By comparing them with the recorded ASSRs,we examined the differences on the featured waves and the ASSR morphology.Results showed the peak-peak amplitudes of V-Na and the latencies of wave-Vs were close,and no statistic difference between recorded ASSR and synthetic ASSR at 36. 8 and 39. 1 Hz,whereas the minimum relative error of 7. 95% was achieved at 36. 8 Hz ASSR. It can be concluded that the stimulus rate has little effect on the responses within these range,which justifies the applicability of the MSAD method.