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Rho-GTPases参与肾小球足细胞骨架调节的研究进展 被引量：3

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摘要 肾小球足细胞是肾脏固有细胞之一,在多种肾小球疾病的发生和发展过程中起着关键作用,其结构和功能的维持主要依赖于以肌动蛋白为主的细胞骨架及其调节系统。Rho-GTPases在肌动蛋白细胞骨架调节中发挥着核心作用。RhoA、Ras相关C3肉毒素底物1(Rac1)和细胞分裂周期蛋白42(Cdc42)是Rho-GTPases的重要成员。本文就近年来RhoA、Rac1和Cdc42在肾小球足细胞骨架调节方面的研究进展作一综述。
作者 赵建月 王江丽 刘茂东 李英
机构地区 河北医科大学第三医院肾内科
出处 《临床荟萃》 CAS 2016年第6期693-696,共4页 Clinical Focus
关键词 肾小球 足细胞 ρGTP结合蛋白质类
分类号 R322.61 [医药卫生—人体解剖和组织胚胎学]
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参考文献34

  • 1Mundel P,Kriz W. Structure and function of podocytes: anupdate[J], Anat EmbryoKBerl),1995,192(5) . 385-397.
  • 2Fu Z, Chen Y,Qin F, et al. Increased activity of Rho kinasecontributes to hemoglobin-induced early disruption of theblood-brain barrier in vivo after the occurrence of intracerebralhemorrhage[J], Int J Clin Exp Pathol,2014, 7(11): 7844-7853.
  • 3Ridley AJ. Rho GTPases and cell migration[J]. J Cell Sci,2001, 114(Pt 15): 2713-2722.
  • 4Etienne-Manneville S, Hall A. Rho GTPases in cell biology[J]. Nature,2002,420(6916): 629-635.
  • 5Beveridge RD, Staples CJ, Patil AA, et al. The leukemia-associated Rho guanine nucleotide exchange factor LARG isrequired for efficient replication stress signaling[J]. Cell Cycl,2014, 13(21): 3450-3459.
  • 6Welsh GI, Saleem MA. The podocyte cytoskeleton--key to afunctioning glomerulus in health and disease [ J]. Nat RevNephrol,2012,8(1); 14-21.
  • 7Faul C,Donnelly M,Merscher-Gomez S,et al. The actincytoskeleton of kidney podocytes is a direct target of theantiproteinuric effect of cyclosporine A[J]. Nat Med, 2008, 14(9): 931-938.
  • 8Asanuma K, Yanagida-Asanuma E, Faul C, et al.Synaptopodin orchestrates actin organization and cell motilityvia regulation of RhoA signalling [J]. Nat Cell Biol, 2006, 8(5): 485-491.
  • 9Attias O, Jiang R, Aoudjit L, et al. Racl contributes to actin organization in glomerular podocytes [J ]. Nephron Exp Nephrol,2010, 114(3): e93-e106.
  • 10Gao SY, Li CY, Chen J, et al. Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted process elongation [J]. NephronExp Nephrol,2004, 97(2): e49-e61.

二级参考文献6

  • 1Shah DI, Singh M. Involvement of Rho-kinase in experimental vascular endo*helial dysfunction[J]. Mol Cell Biochem, 2006, 283(1/2) :191-199.
  • 2Nohria A,Grunert ME, Rikitake Y, et al. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease[J]. Circ Res,2006,99(12) :1426-1432.
  • 3Shibuya M, Hirai S, Seto M, et aI. Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double blind trial[J]. J Neurol Sci, 2005,238 ( 1/2) : 31-39.
  • 4Satoh S, Toshima Y, Ikegakil I, et al. Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils[J]. Brain Res, 2007,1128( 1 ) : 175 180.
  • 5Rikitake Y, Kim HH, Hung Z, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection[J]. Stroke, 2005,36 (10) : 2251 2257.
  • 6Shibuya M, Hirai S, Seto M, et al. Effects of fasudil in acute isehemic stroke: results of a prospective placebo controlled double-blind trial[J]. J Neurol Sci, 2005,238 ( 1/2 ) : 31-39.

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临床荟萃
2016年 第6期

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