类克输注开始时间精确输液滴数调节对发生不良反应患者的影响

Effects of accurate start time of infusion and regulation of infusion drips on adverse reactions of Infliximab

目的:观察类克治疗中,精确输注开始时间时输液滴数的调节,对发生不良反应患者的影响。方法:将400例次使用类克治疗的风湿病患者按时间的先后顺序随机分为对照组和观察组,每组各200例。对照组患者采用将头皮针连接输液器中生理盐水作为引液开始输注类克,并计算输注开始时间及输液滴数;观察组患者采用头皮针连接注射器建立静脉通路后直接连接类克稀释液,并计算输注开始时间及输液滴数。比较两组患者的不良反应发生率。结果:观察组患者的不良反应发生率明显低于对照组(P<0.05)。结论:精确类克输注开始时间的滴数调节可有效降低不良反应发生率。

Objective：To explore effects of accurate start time and regulation of infusion drips on adverse reactions of Inflix-imab infusion. Methods：400 rheumatic patients injected with Infliximab were divided into control group and observation group accord-ing to the order of time （200 cases in each group）. The control group was injected by connecting scalp needle to saline （as lead liq-uid） in infusion apparatus, and the start time and infusion drips were calculated, while the observation group was administered by con-necting scalp needle to syringe, which was then connected to diluted infliximab, and the start time and infusion drips were calculated. The incidences of adverse reactions of the two groups were compared. Results：The incidence of adverse reactions of observation group was significantly lower than that of control group （P〈0. 05）. Conclusions：Accurate start time and regulation of infusion drips of In-fliximab infusion can effectively reduce the incidence of adverse reactions.