摘要
目的探讨合成盐酸西那卡塞的新方法。方法以3-(3-三氟甲基苯基)丙醇为原料,经二甲基亚砜/五氧化二磷氧化成醛、三氟甲磺酸铁催化的还原氨化、成盐三步反应,合成了盐酸西那卡塞。结果及结论该方法采用对环境友好的反应试剂,反应步骤少,操作简单,总收率高(57.8%)。
Objective A new method was developed for the synthesis of cinacalcet hydrochloride. Methods Cinacal-cet hydrochloride was prepared from 3 -（3 - trifluoromethylphenyl）- 1 - propanol via three steps,including DMSO/ P2 O5 mediated oxidation,iron triflate catalyzed reductive amination of aldehydes using sodium borohydride,and finally hydrochlo-ride formation. Results and Conclusion This method used environmentally benign reagents to prepare cinacalcet hydro-chloride in only three steps with an overall good yield of 57. 8% .
出处
《药学研究》
CAS
2016年第7期425-426,430,共3页
Journal of Pharmaceutical Research
关键词
盐酸西那卡塞
合成
催化还原氨化
Cinacalcet Hydrochloride
Synthesis
Catalytic reductive amination
