hsa-miR-1249和hsa-miR-486-5p与Ⅱ型糖尿病的相关性研究

Relationship between hsa-miR-1249 and has-miR-486-5p and Type 2 Diabetes

microRNAs(miRNAs)是一类普遍存在于真核细胞的非编码小分子RNA,通常在转录后水平抑制靶基因的表达。miRNA表达失调与许多疾病相关,如Ⅱ型糖尿病(T2D)。Ⅱ型糖尿病是一种复杂的疾病,显著特征是高血糖。近年来的研究表明,miRNA在Ⅱ型糖尿病的发生发展中扮演着不同的角色。本研究通过miRNA微阵列芯片和实时荧光定量PCR的方法,发现hsa-miR-1249和hsa-miR-486-5p在Ⅱ型糖尿病患者血浆中较之于正常对照组表达显著降低,显示了hsa-miR-1249和hsa-miR-486-5p可能在Ⅱ型糖尿病的发病过程中起着重要的作用。本研究揭示了hsa-miR-1249和hsa-miR-486-5p有可能成为Ⅱ型糖尿病的新的诊断标志物和治疗靶标。

MicroRNAs （ miRNAs） are a family of small nonprotein-coding RNAs. They inhibit the expression of target gene at post-transcriptional level. Dysregulation of miRNAs has been linked to many diseases, such as type 2 diabetes （T2D）. T2D is a complex disease characterized by high blood glucose levels. Recent studies have shown that miRNAs play diverse roles in T2D. In this study, miRNA microarray and real-time PCR were performed. The study found that the expression of hsa-miR-1249 and hsa-miR-486-5p were significantly lower in T2D plasma sample compared with healthy control plasma sample. It showed that hsa-miR-1249 and hsa-miR-486-5p may play vital roles in the development of type 2 diabetes mellius. It was revealed that hsa-miR-1249 and hsa-miR486-5p may serve as novel biomarkers for diagnosis and potential targets for the treatment of T2D.