癫痫患者的认知功能评估及其影响因素研究

Assessment of cognitive function and the analysis of influencing factors for patients with epilepsy

目的评估癫痫患者的认知功能,探索影响癫痫患者认知功能的相关因素。方法将2013年1月-2015年1月在三台县人民医院就诊的符合国际抗癫痫联盟(ILAE)1981年癫痫发作分类及1989年癫痫综合征分类标准的癫痫患者48例作为研究组,选取同期在该院的45例健康体检者为对照组。采用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评价两组的认知功能,采用自制调查表收集患者的病历资料,并分析影响癫痫患者认知功能的相关因素。结果研究组MoCA总评分低于对照组[(19.34±7.22)分vs.(28.61±6.89)分],差异有统计学意义(P<0.01),MoCA各项目评分研究组低于对照组,差异均有统计学意义(P<0.01)。发病年龄、病程长短、发作频率、发作持续时间、发作类型及用药情况对患者的认知功能影响显著(P均<0.05)。结论癫痫患者存在认知功能障碍,其认知功能损害与发病年龄、病程长短、发作频率、发作持续时间、发作类型及用药情况有关。

Objective To evaluate the cognitive function and analyze the factors of affecting cognitive function for patients withepilepsy. Methods From Jan. 2013 to Jan. 2015, a total of 48 patients （ study group） with epilepsy who met the diagnostic standardsof International League Against Epilepsy （ ILAE） and 45 healthy controls （ control group） were included in the study. MontrealCognitive Assessment （ MoCA） was used to assessed the cognitive function of all participants. The data of study group were collected toanalyze the factors of affecting cognitive function for patients with epilepsy. Results Compared with control group, the total score ofMoCA of study group was lower, the difference was statistically significant （P 〈 0 .0 1 ）. The scores in each factors of MoCA in studygroup were lower than control group （P 〈0. 01）. The factors related to the cognitive function of patients with epilepsy included age ofepilepsy onset, duration of epilepsy, seizure frequency, duration of seizures, seizure type and types of medication （P 〈 0. 05）.Conclusion Patients with epilepsy has cognitive dysfunction and the influencing factors include age of epilepsy onset, duration ofepilepsy, seizure frequency, duration of seizures, seizure type and types of medication.