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肾损伤因子1对冠状动脉造影术后对比剂肾病发生的预测价值 被引量:1

Predictive value of kidney injury factor 1 in contrast-induced nephropathy coronary arteriography
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摘要 目的分析肾损伤因子1(Kim-1)对冠状动脉造影术后对比剂肾病发生的预测价值。方法依据接受冠状动脉造影检查患者冠状动脉造影术后是否发生对比剂肾病(CIN)分为两组,观察组(术后CIN)及对照组(无CIN)。比较两组的术后24 h尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及Kim-1水平。结果本研究共纳入患者76例,其中观察组31例,对照组45例。观察组患者Kim-1水平显著高于对照组,差异有统计学意义(t=4.765,P<0.01);观察组患者尿NGAL水平显著高于对照组,差异有统计学意义(t=3.157,P<0.01)。Pearson相关性检验显示,观察组患者NGAL水平与Kim-1水平呈现显著正相关,差异有统计学意义(r=0.675,P<0.01)。ROC曲线分析显示,当Kim-1取值为4.71μg/L时,对比剂肾病发生的预测敏感性为83.87%,特异性为84.44%,优于NGAL。结论 Kim-1可用以辅助预测冠状动脉造影术后对比剂肾病的发生。 Objective To analyze the predictive value of kidney injury factor 1 (Kim-1 )in contrast-induced nephropathy after coronary arteriography.Methods Clinical data of patients received coronary arteriography in our hos-pital from 2010 to 2016 were analyzed.Patients were divided into two groups by whether patients had contrast-induced nephropathy (CIN)after coronary arteriography,including observation group (CIN)and control group (no CIN).Re-sults A total of 76 patients were collected in this study,31 cases were in observation group while 45 in control group. The Kim-1 and neutrophil gelatinase-associated lipocalin (NGAL)in observation group were significant higher than those in control group (P 〈0.05).Correlation analysis showed that Kim-1 was correlated positively and significantly with NGAL (r =0.675,P 〈0.01).ROC analysis showed that the value of Kim-1 was 4.71 μg/L,the sensitivity and specificity of prediction of CIN after coronary arteriography was 83.87%,84.44% respectively.Conclusion Kim-1 can be used as a predictive index of CIN after coronary arteriography.
出处 《中国临床保健杂志》 CAS 2016年第4期369-371,449,共4页 Chinese Journal of Clinical Healthcare
关键词 肾疾病 冠状血管造影术 脂蛋白质类 诊断技术 泌尿科 Kidney diseases Coronary angiography Lipocalins Diagnostic Techniques,urological
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  • 1沈辉,潘军,汪军,徐振华.欧乃派克引发特殊迟发过敏反应的分析及对策[J].实用医技杂志,2006,13(5):710-711. 被引量:9
  • 2全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. 被引量:710
  • 3王玲,倪兆慧,何奔.对比剂肾病研究进展[J].介入放射学杂志,2007,16(1):66-69. 被引量:12
  • 4张龙江,祁吉.对比剂肾病:一个值得关注的问题[J].中华放射学杂志,2007,41(8):882-884. 被引量:69
  • 5Nash K, Hafeez A, Hou S. Hospital-acquired renal insufficiency [J]. Am J Kidney Dis, 2002,39(5) :930-936.
  • 6Gruberg L, Mintz G S, Mehran R, et al. The prognostic implica- tions of further renal function deterioration within 48 h of inter- ventional coronary procedures in patients with pre-existent chron- ic renal insufficiency[J] . J Am Coil Cardiol, 2000,36 (5) : 1542- 1548.
  • 7Stacul F,van der Molen A J,Reimer P,et al. Contrast induced ne- phropathy: updated ESUR Contrast Media Safety Committee guidelines[J]. Eur Radiol, 2011,21 (12) : 2527- 2541.
  • 8Asif A, Epstein M. Prevention of radiocontrast-induced nephropa- thy [J] Am J Kidney Dis,2004,44(1):12-24.
  • 9Mcclulough P A. Contrast-induced acute kidney injury[J]. J Am Coll Cardiol,2008,51(15) :1419-1428.
  • 10Waybill M M, Waybill P N. Contrast media-induced nephropa- thy: identification of patients at risk and algorithms for preven- tion [J]. J Vasc Interv Radiol,2001,12(1):3-9.

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