丁香柿楴汤合洛贝林治疗顽固性呃逆的临床观察

Effect of Dingxiang persimmon stem decoction combined with lobeline on intractable hiccup

目的观察丁香柿楴汤合并洛贝林治疗顽固性呃逆临床疗效和不良反应。方法选自60例顽固性呃逆患者,根据就诊先后随机分为研究组(丁香柿楴汤合洛贝林)和对照组(洛贝林)各30例。对照组给予洛贝林3 mg肌注,1次/天,研究组加服丁香柿楴汤。对两组病例治疗前后有效率、起效时间及病程分别进行对比观察。结果在起效时间方面,研究组优于对照组,差异有统计学意义(P<0.05)。在疗程方面,研究组疗程较对照组明显缩短,差异有统计学意义(P<0.05)。在有效率方面,研究组24 h、48 h、72 h、96 h有效率分别为76.7%、90.0%、100.0%、100.0%;对照组24 h、48 h、72 h、96 h有效率分别为53.3%、70%、80%、83.3%,研究组有效率优于对照组(P<0.05)。结论丁香柿楴汤合洛贝林治疗顽固性呃逆临床疗效是可靠的,未发现明显不良反应,值得临床推广。

Objective To observe the effect and adverse reactions of Dingxiang persimmon stem decoction combined with lobeline on intractable hiccup.Methods Sixty patients with intractable hiccup were randomly divided into experimental group （Dingxiang persimmon stem decoction combined with lobeline）and control group （lobeline）, patients in each group.The control group was given 3 mg lobeline intramuscular injection,once a day.Patients in experi-mental group were given lobelinec ombined with Dingxiang persimmon stem decoction.The efficiency,onset time and course of disease were compared between the two groups before and after treatment.Results The onset time and dura-tion of experimental group were shorter than those in the control group,there were significant differences between the two groups （P 〈0.05）.The effective rates of experimental group at 24,72,48,96 hours were 76.7%,90.0%,100.0%, 100.0% respectively;and the rates of control group were 53.3%,70.0%,80.0%,83.33% respectively,the experi-mental group was more efficient than the control group （P 〈0.05）.Conclusion Dingxiang persimmon stem decoction combined with lobeline is effective in the treatment of intractable hiccup without obvious side effects.