巨噬细胞移动抑制因子在诊断老年肾病综合征合并脑梗死患者的临床应用

Clinical application of MIF in the diagnosis of elderly nephrotic syndrome patients with cerebral infarction

目的研究巨噬细胞移动抑制因子(MIF)在老年肾病综合征合并脑梗死患者判断价值与临床应用。方法分析84例肾病综合征患者的临床资料,将其中合并患有脑梗死的40例患者列为观察组,仅患有肾病综合征的44例患者划为对照组。采用双夹心酶联免疫吸附试验测定MIF在老年肾病综合征合并脑梗死患者的血清水平。结果观察组患者血清中三酰甘油(TG)含量明显高于对照组,差异有统计学意义(t=2.792,P=0.007),两组研究对象在总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平比较上,差异无统计学意义(P>0.05);观察组患者血清中同型半胱氨酸(Hcy)(t=2.601,P=0.011)、MIF(t=2.973,P=0.004)、超敏C反应蛋白(hs-CRP)(t=2.143,P=0.035)指标水平高于对照组,差异有统计学意义(P<0.05);观察组患者TG与Hcy(r=0.365,P=0.020)、MIF(r=0.477,P=0.002)、hs-CRP(r=0.357,P=0.024)呈正相关;当MIF取值为0.856μg/L时对肾病综合征合并脑梗死的诊断敏感性为92.52%,特异性为88.64%。结论 MIF可以作为判诊断肾病综合征合并脑梗死患者的有效指标。

Objective To study the clinical application of MIF in the diagnosis of elderly nephrotic syndrome patients with cerebral infarction.Methods Clinical data of 84 patients with nephrotic syndrome were analyzed,ne-phrotic syndrome patients with cerebral infarction as the observation group,patients with nephrotic syndrome as con-trol group.MIF were measured by ABC-ELISA.Results The TG in the observation group was significantly higher than that in control group（t =2.792,P =0.007）.No significant difference was found between the two groups in TC, HDL and LDL-C （P 〉0.05）.Serum Hcy （t =2.601,P =0.011）,MIF （t =2.973,P =0.004）,and hs-CRP（t =2.143,P =0.035）in the observation group were higher than those in control group,a statistically significant differ-ence （P 〈0.05）.TG had a positive correlation with Hcy （r =0.365,P =0.020）,MIF（r =0.477,P =0.002）, hs-CRP（r =0.357,P =0.024）in observation group.When the MIF value was 0.856 μg/L,the sensitivity of the di-agnosis of nephrotic syndrome with cerebral infarction was 92.52%,specificity was 88.64%.Conclusions MIF can be used as a effective index in the clinical diagnosis of nephrotic syndrome patients with cerebral infarction.