免疫组化在上皮性皮肤肿瘤诊断中的应用进展

Application of immunohistochemistry in the diagnosis of epithelial skin tumors

上皮性皮肤肿瘤是指来源于皮肤角质形成细胞或皮肤附属器的肿瘤。上皮源性皮肤肿瘤诊断主要依靠形态学特征，在某些诊断困难情况下，免疫组化是一个有价值的辅助诊断指标。包括鉴别肿瘤起源，肿瘤良恶性及原发或者转移性上皮源肿瘤。有时候，需要组合数个抗体来进行明确诊断。在临床实践中对组化结果需要小心解释并结合组织学特征，才能出正确诊断。

Epithelial skin tumors are derived from keratinocytes and skin appendages. Their diagnosis mainly depends on morphological features. In some cases difficult to diagnose, immunohistochemistry may be a valuable auxiliary diagnostic tool, which can be used to identify tumor origin and differentiate between benign and malignant neoplasms as well as between primary and metastatic epithelial tumors. Sometimes, several antibodies are needed to be assembled to make a definitive diagnosis. In clinical practice, careful interpretation of immunohistochemical findings and combination of histological features are warranted for a correct diagnosis.