降钙素基因相关肽对朗格汉斯细胞功能影响的研究进展

Effects of calcitonin gene-related peptide on functions of Langerhans cells

在慢性炎症性皮肤病的神经免疫调节过程中，神经肽对于皮肤免疫细胞的调节作用受到越来越多的重视。在精神紧张、应激和压力的作用下，皮肤局部神经纤维产生降钙素基因相关肽，调节皮肤的朗格汉斯细胞。朗格汉斯细胞是表皮中重要的专职抗原提呈细胞。近年来发现，降钙素基因相关肽不仅可以影响朗格汉斯细胞的增殖、分化，而且影响其抗原提呈功能。降钙素基因相关肽可以抑制朗格汉斯细胞核因子κB通路的活化、抑制其协同刺激分子的表达，进而影响朗格汉斯细胞介导的免疫反应。

The regulatory effects of neuropeptides on skin immune cells in the neuroimmunomodulation process have gained more and more attention in chronic inflammatory skin diseases. Under psychentonia, stress and pressure, nerve fibers in local skin produce calcitonin gene-related peptide （CGRP） to regulate Langerhans cells, which are professional antigen-presenting cells in the epidermis. Recent studies have found that CGRP can affect not only the proliferation and differentiation of Langerhans cells, but also their antigen-presenting capacity. Moreover, CGRP can influence Langerhans cell-induced immune reactions by inhibiting the activation of nuclear factor kappa B （NF-κB） signaling pathway and of costimulatory molecules.