基因芯片在痘病毒对宿主基因转录调控中的应用

Application of gene microarray on host cell gene transcription regulated by poxvirus

痘病毒(Poxvirus)是病毒颗粒最大的一类DNA病毒,结构复杂;感染人和动物后常引起局部或全身化脓性皮肤损害,给畜牧业带来严重的经济损失同时也威胁着人类健康。痘病毒可通过多种策略调控宿主基因的转录进而影响其免疫应答。基因芯片通过对宿主细胞在病毒感染前后基因表达谱的检测,为病毒的致病机制及病毒感染对宿主的调控机制的研究提供了便利手段。本文综述了有关基因芯片在痘病毒研究中的应用。

Poxvirus is the largest DNA virus,containing complicated structure.It can cause local or systemic purulent damage to skin after infection of humans or animals.Furthermore,it brings about serious economic loss to livestock and threatens human health.Poxvirus could regulate and controlle host cell gene transcription by a variety of strategies,which in turn affect the host immune response.Gene microarray provides a convenient mean for studying the pathogenic mechanism of virus and regulatory mechanism of the host by detection of the host cell gene expression profile before or after the poxvirus infection.This paper reviews the related application of gene microarray on the poxvirus research.