肿瘤患者血清NT-proBNP、TNI和CK-MB水平及其临床意义

A Study on the Serum levels and Clinical significances of NT-proBNP, TNI and CK-MB in Cancer Patients

目的探讨肿瘤患者血清NT-pro BNP、TNI和CK-MB水平及其临床意义。方法收集深圳市南山区人民医院2010年10月至2015年10月住院治疗的249例肿瘤患者(肿瘤组)和250例正常体检的患者(对照组),排除有冠心病、心力衰竭等疾病,检测和比较其血清NT-pro BNP、TNI和CK-MB水平,并分析其与肿瘤患者死亡风险的相关性。结果肿瘤组初发阶段血清TNI为(0.085±0.0135)ng·m L^(-1),NT-pro BNP水平为(78.45±19.61)pg·mL^(-1),均较对照相显著升高,差异具有统计学意义(P<0.001);两组血清CK-MB水平比较差异不具有统计学意义(P=0.654)。随着肿瘤分期的进展,患者血清NT-pro BNP、TNI和CK-MB水平逐渐升高,不同分期之间比较,差异均具有统计学意义(P<0.05)。血清NT-pro BNP、TNI和CK-MB水平与肿瘤患者的死亡风险相关,其值越高,患者的死亡风险越大。结论肿瘤患者的血清NT-pro BNP和TNI水平可能作为判断肿瘤患者病情进展和进行预后评估的参考指标。

Objectives To investigate the serum levels and clinical significances of NT-proBNP,TNI and CK-MB in cancer patients. Methods 249 cases of cancer patients （the tumor group） hospitalized in Shenzhen Nanshan District People＇ s Hospital from October 2010 to October 2015 and 250 physically normal patients （the control group） were included in this project. The coronary disease and heart failure were excluded. The NT-proBNP and TNI as well as CK-MB levels were detected and compared, and their correlation with the risk of death was analyzed. Results During the primary stage of cancer,the serum levels of TNI and NT-proBNP were respectively （0.085 ＋ 0.0135）ng·mL^-l and （78.45 ＋ 19.61）pg·mL^-1 Both were significantly higher than those of the control group （P 〈 0.001）. However, there was no statistically significant difference in serum CK-MB levels between the two groups （P= 0.654）. With the progression of tumor stage, the serum levels of NT-proBNP, TNI and CK-MB increased significantly, and significant difference between different stages were observed （P〈0.05）. The serum levels of NT-proBNP,TNI and CK-MB were positively correlated with the death risk. The higher the serum levels of NT-proBNP,TNI and CK-MB were, the higher the death risk was. Conclusions The serum NT-proBNP and TNI levels could be used as references in evaluating the progress and prognosis of cancer patients.