支气管肺泡灌洗与局部注药在支气管扩张合并感染患者治疗中的应用

Application of Bronchoalveolar Lavage and Local Injection in Treatment of Patients with Bronchiectasia and Infection

目的探讨支气管肺泡灌洗与局部注药在支气管扩张合并感染患者治疗中的应用。方法整群选取2014年1月—2016年1月该院综合内科收治的支气管扩张合并感染的86例患者,随机分为观察组和对照组,各43例。对照组给予常规治疗方案进行治疗,观察组在常规治疗措施的基础上,加用支气管肺泡灌洗并局部应用敏感抗菌药物,比较两组的临床疗效和治疗前后的血气分析变化。结果观察组显效率和总有效率为83.72%、100.00%,明显高于对照组的67.44%、90.70%,差异有统计学意义(P<0.05)。治疗后,对照组血氧分压明显高于治疗前,血二氧化碳分压明显低于治疗前;观察组的血氧分压明显高于治疗前和对照组治疗后,血二氧化碳分压明显低于治疗前和对照组治疗后。差异有统计学意义(P<0.05)。结论支气管肺泡灌洗与局部注药治疗支气管扩张合并感染,能够更有效的控制感染,纠正患者的缺氧状态,提高本病的临床疗效,值得进一步推广应用。

Objective To discuss the clinical curative effect of bronchoalveolar lavage and local injection in treatment of patients with bronchiectasia and infection and provide reference for the clinical treatment strategy formation. Methods 86 cases of patients with bronchiectasia and infection admitted and treated in the comprehensive medicine department of our hospital from January 2014 to January 2016 were selected and randomly divided into two groups with 43 cases in each, the control group were treated with the conventional method, the observation group were treated with bronchoalveolar lavage and local application of sensitive antibiotic drugs, and the clinical curative effects and changes in the blood gas analysis were compared between the two groups. Results The excellent rate and total effective rate in the observation group were obviously higher than those in the control group,（83.72%, 100.00% vs 67.44%, 90.70%）, and the differences had statistical significance, P〈0.05, the differences in the partial pressure of blood oxygen and partial pressure of blood carbon dioxide between the two groups before treatment had no statistical significance, P〈0.05, after treatment, the partial pressure of blood oxygen in the control group was obviously higher than that before treatment, the partial pressure of blood carbon dioxide in the observation group was lower than that before treatment and that in the control group after treatment, and the differences had statistical significance（all P〈0.05）. Conclusion Bronchoalveolar lavage and local injection in treatment of bronchiectasia and infection can effectively control infection, correct the anaerobic condition of patients and improve the clinical curative effect of the disease, which is worth further promotion and application.