神经元特异性烯醇化酶在新生儿缺氧缺血性脑病中的诊断价值

Diagnostic value of serum neuron-specific enolase in neonatal hypoxic-ischemic encephalopathy

目的探讨血清神经元特异性烯醇化酶(NSE)在新生儿缺氧缺血性脑病(HIE)中的早期诊断价值。方法选取该科2013年1月至2014年6月收治的足月HIE患儿80例(观察组),同期入住该科无围产期窒息史的足月新生儿30例作为对照组,观察组分别于出生后24h内、综合治疗2周(主要包括神经节苷脂治疗10d)检测血清NSE,根据病情程度将观察组患儿分为轻度HIE 18例、中度HIE 48例、重度HIE 14例。对照组于生后24h内检测血清NSE。结果轻、中、重度HIE组血清NSE检测结果明显高于对照组(P<0.05)。HIE患儿综合治疗2周后复查血清NSE,轻、中、重度HIE组均较入院时明显降低,差异有统计学意义(P<0.05)。结论血清NSE是新生儿HIE早期诊断的敏感生化指标,还可反映新生儿HIE的严重程度。

Objective To investigate the early diagnostic value of serum neuron‐specific enolase（NSE） in neonaal hypoxic‐is‐chemic encephalopathy（HIE） .Methods Eighty full term neonates with HIE in the neonatology department of our hospital from January 2013 to June 2014 were selected as the observation group and contemporaneous 30 full term neonates without perinatal as‐phyxia as the control group .Serum NSE was detected within 24 h after birth and after 2‐week comprehensive treatment（mainly in‐cluding 10 d ganglioside therapy） .The neonatal patients were divided into the mild HIE in 18 cases ,moderate HIE in 48 cases and severe HIE 14 cases according to the HIE severity .The control group was performed the serum NSE detection within postnatal 24 h .Results The serum NSE level in the mild ,moderate and severe HIE groups was significantly higher than that in the control group（P〈0 .05） .The re‐detected results of serum NSE after 2‐week comprehensive treatment in the mild ,moderate and severe HIE groups were significantly decreased when compared with those at admission ,the differences were statistically significant（P〈0 .05） .Conclusion Serum NSE is a sensitive biochemical indicator for early diagnosing neonatal HIE ,and also reflect the severity of neonatal HIE .