年龄和宫腔内人工授精周期次数对妊娠的影响

Influence of age and cycles of intrauterine insemination within the uterus on pregnancy by infertile women

目的探讨不孕妇女年龄和宫腔内人工授精周期次数对妊娠的影响。方法统计分析反复宫腔内人工授精的322例不孕不育夫妇临床资料。结果 322对不孕不育夫妇共计行582次宫腔内人工授精周期,最终临床妊娠72例,临床妊娠率12.37%。年龄≥35岁不孕妇女的生化妊娠率和临床妊娠率均低于〈30岁、30~34岁不孕妇女;反复宫腔内人工授精周期次数≥3次不孕妇女的临床妊娠率低于周期1次、2次妇女,差异均具有统计学意义（P〈0.05）。结论不孕妇女年龄和反复宫腔内人工授精周期次数均对妊娠率产生直接影响。

Objective To investigate the influence of age and cycles of intrauterine insemination within the uterus on the pregnancy by infertile women. Method The clinical data of 322 infertile couples（ 582 cycles of intrauterine insemination）were statistically analyzed. Findings Among the 322 infertile couples subjected to 582 cycles of intrauterine insemination,72 cases successfully became pregnant. The clinical success rate was 12. 37%. The biochemical pregnancy and clinical pregnancy rate of infertile women ≥35 years old were significantly lower than that of the infertile women 30 years,30-34 years old（ P〈0. 05）; The clinical pregnancy rate of infertile women with cycles of intrauterine insemination ≥3and≥35years was significantly lower than that with cycle 1,2 women（ P〈0. 05）. Conclusion Age and cycles of intrauterine insemination within the uterus have direct impact on the success rate of pregnancy by infertile women.