女性血清睾酮水平与代谢综合征的相关性分析

The correlation of the level of serum testosterone to metabolic syndrome in women

目的分析女性血清睾酮水平与代谢综合征之间的相关性。方法选取437例就诊以及健康体检的40岁以上妇女,根据PENN-5分期标准分为月经正常、绝经过渡期、绝经早期、绝经中期和绝经晚期妇女;检测血清睾酮水平,统计代谢综合征例数。结果 437例妇女血清睾酮水平中位值0.60 nmol/L,相比月经正常妇女,其他不同绝经状态下妇女睾酮水平均明显下降（P〈0.05）;437例妇女中发生代谢综合征91例,不同绝经状态下代谢综合征发生率比较差异有统计学意义（χ^2=19.461,P=0.001）。低睾酮水平、中睾酮水平和高睾酮水平组的代谢综合征比例分别为23.6%、20.5%和18.2%。结论低水平的睾酮可能是40岁以上妇女代谢综合征潜在危险因素,绝经后女性血清睾酮水平是预测绝经后女性代谢综合征的一个可选指标。

Objective To find out the possible correlation of the level of serum testosterone to metabolic syndrome in female patients. Method Four hundred thirty-seven women over 40 years of age were chosen as the subjects of the study. According to PENN- 5 stages,the subjects were divided into 5 groups,namely,group A（ of women having normal menstruation）,group B（ of women having perimenopause）,group C（ of women having early menopause）,group D（ of women having middle menopause）,and group E（ of women having late menopause）. The testosterone level was detected with automated chemiluminescent method. The correlation of serum testosterone level to metabolic syndrome was analyzed by using SPSS16. 0. Findings The median testosterone level in 437 women was 0. 60 nmol / L. Compared to that of group A,he testosterone level in women experiencing menopause dropped significantly（ P〈0. 05）. Of 437 women,91 women suffered metabolic syndrome. The rates of metabolic syndrome observed in the groups experiencing menopause varied and the difference among them was statistically significant（ χ^2= 19. 461,P = 0. 001）. The rates of metabolic syndrome in the group with low level of testosterone,the group with middle level of testosterone,and the group with high level of testosterone were23. 6%,20. 5% and 18. 2%,respectively. Conclusion Low level of testosterone may become a risk factor that gives rise to metabolic syndrome and thus the level of testosterone can serve as an important variable in the diagnosis of metabolic syndrome in women with menopause.