女性骨关节炎骨质疏松危险因素分析

Risk factors for osteoporosis in female patients with osteoarthritis

目的：探讨女性骨关节炎（OA）骨质疏松（OP）的危险因素。方法：使用双能X线骨密度仪测定300例女性OA患者（OA组）和101名健康女性（对照组）第1-4腰椎（L1-4）、股骨颈、全髋等部位骨密度（BMD）。统计分析各组与OP相关的危险因素。结果：女性OA患者OP发生率显著高于健康女性（P〈0.01）,各部位BMD均低于对照组（P〈0.01）。OA患者OP组各部位BMD均明显低于非OP组（P〈0.01）,OA患者绝经后组各部位BMD均低于绝经前组（P〈0.01）,OA患者OP组较非OP组年龄更大,绝经时间更长,孕产次数更多（P〈0.01）。OA组OP女性未来10年骨折的概率明显高于对照组（P〈0.01）。结论：女性OA患者发生OP和骨折风险均显著高于健康女性,其OP的发生和多因素相关,增龄、绝经年限长、孕产次数多是OA患者发生OP的主要危险因素。

Objective： To study the risk factors for osteoporosis （OP） in female patients with osteoarthritis （OA）. Methods： The bone mineral density（BMD） in the lumbar vertebrae（ L1-4 ） ,femoral neck and total femoral area of 300 female patients with OA and 101 female healthy subjects were measured by dual energy X-ray absorptiometry. The risk factors for OP were analyzed statistically in each group. Results：The incidence of OP in the female patients with OA was significant higher than that in the healthy subjects （P 〈 0.01 ）. The BMD of all positions in the female patients with OA was lower than that in the healthy subjects （ P 〈 0.01 ）. Of all the patients with OA, those who had been diagnosed as having OP had lower BMD than those who had not （P 〈 0.01 ）. The BMD in the menopause group with OA was lower than that in the pre-menopausal group. Of all the patients with OA, the OP group had elder ages, longer years of menopause and more numbers of motherhood. And the differences were all statistically significant （ P 〈 0.01 ）. The probability of osteoporotic fracture in patients with OA was obviously higher than that in healthy subjects in the next 10 years （ P 〈 0. 01 ）. Conclusions ：Compared with the healthy subjects, patients with OA are more easily affected by OP and osteoporotic fracture. The incidence of OP is related to several risk factors such as elder ages,longer years of menopause and more numbers of motherhood.