血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系

The correlation of the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the type 2 diabetic nephropathy

目的:测定血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGF-BP3)水平,探讨其与2型糖尿病肾病的关系。方法:选择2型糖尿病患者86例,根据其尿微量白蛋白排泄率(UAER)结果分为单纯糖尿病组(SDM组)33例、早期糖尿病肾病组(EDN组)28例和临床期肾病组(CDN组)25例。检测IGF-1、IGF-BP3、UAER等指标,分析IGF-1、IGF-BP3与糖尿病肾病的发病和病情轻重的关系。结果:CDN组血清IGF-1、IGF-BP3和UAER均明显高于SDM与EDN组(P<0.01),CDN组血清IGF-1、IGF-BP3和UAER亦均明显高于EDN组(P<0.01)。IGF-1与肌酐、尿素氮、UAER和IGF-BP3均呈正相关关系(P<0.01),与年龄和糖化血红蛋白均无相关关系(P>0.05),而与空腹血糖呈负相关关系(P<0.01)。结论:血清IGF-1、IGF-BP3水平与2型糖尿病肾病的发生发展有相关性,可作为糖尿病肾病早期的诊断指标之一。

Objective：To measure the serum levels of insulin-like growth factor-1 （ IGF-1 ） and insulin-like growth factor binding protein-3（ IGF-BP3 ） in patients with type 2 diabetic nephropathy, and explore its correlation with type 2 diabetic nephropathy. Methods：According to the results of the urinary albumin excretion rate（ UAER） ,86 patients with type 2 diabetes were divided into the simple diabetes group （ SDM group, 33 cases ） , early diabetic nephropathy group （ EDN group, 28 cases ） and clinical stage of nephropathy group（CDN group,25 cases）. The levels of the IGF-1,IGF-BP3,UAER and other indicators were detected,which was used to analyze the correlations of IGF-1 and IGF-BP3 with diabetic nephropathy. Results：The serum levels of IGF-1 and IGF-BP3 and UAER in CDN group were higher than those in SDM group and CDN group（P〈0. 01）,the serum levels of IGF-1,IGF-BP3 and UAER in CDN group were higher than those in EDN group（P〈0. 01）. The IGF-1 was positive correlation with the creatinine,urea nitrogen, UAER and IGF-BP3,respectively（P〈0. 01）,the IGF-1 was correlation without age and glycosylated hemoglobin（P〉0. 05）,and was negative correlation with fasting plasma glucose（P〈0. 01）. Conclusions：The serum levels of IGF-1 and IGF-BP3 are related to the occurrence and development of type 2 diabetic nephropathy, which can be used as one of the early diagnosis index of diabetic nephropathy.